95 results
The overall goal of our research is to identify host factors responsible for the variability in HIV-1 susceptibility. We hypothesize that host factors that either restrict or enable HIV-1 replication will be additional targets for therapeutic…
1. To investigate the etiology and incidence of respiratory tract infection in children younger than 6 years of age.2. To investigate the course of respiratory tract infections in children younger than 6 years of age.3. To investigate the clinical…
Investigate whether switch from a non-nucleoside reverse transcriptase inhibitor (NNRTI)- or protease inhibitor (PI)-based regimen to a raltegravir-based regimen results in reduced platelet reactivity, reduced platelet-leukocyte aggregate formation…
To estimate the frequency/ prevalence of acute or active HEV infection in patients presenting with (sub)acute post-infectious and/or immune-mediated neurological illness like neuralgic amyotrophy, (idiopathic) Guillain Barre syndrome, idiopathic…
To increase insight in cerebral injury of perinatally HIV-infected children by comparing neurological, ophtalmological and neurocognitive outcomes to those of matched controls (with respect to age, sex, ethnic background, home environment and socio-…
The main objective of this study is to assess effectiveness of the COVID-19 vaccinations, based on humoral (anti-coronavirus antibody) immunity, in GCA and PMR patients. Other objectives are assessing antigen-specific cellular (T-cell) immune…
With this study, we want to gain insight in the SARS-CoV-2 specific immunity (T- and B-cell) of patients with congenital immune disorders. This will add to our knowledge on SARS-CoV-2 specific immunity, and on the immune capacity of the patients…
Primary objective:Investigate if a trained immunity profile in innate immune cells might be a mechanism of HIV elite control.Secondary objectives:1. Determine the immune phenotypes that distinguishes family members of HIV elite controllers from…
To examine the impact of RSV infection on the diversity of the upper respiratory tract microbiome, measured by the Shannon index.
Primary objective: To investigate the baseline systemic immune profile in COVID-19 patients using mRNA expression profiling, and to connect that to clinical outcome in order to identify prognostic and predictive markers that can help in decision…
1. To evaluate if breastmilk of mothers who recovered from a proven COVID-19 infection contains antibodies (IgA) against SARS-CoV2.2. To evaluate if these antibodies are still present after pasteurization according the Holder method.
Therefore, the Precision Medicine for more Oxygen (P4O2) program aims to identify treatable traits and innovative personalized therapeutic strategies to both prevent progression of early stage lung damage and to reverse established lung damage by…
Primary• To describe the incidence, aetiology and viral loads of (a)symptomatic viral respiratory infections in adults (18-40 years) who live in shared housing with at least 3 other adults during the peak common cold season in the…
The aim of this study is to determine whether white blood cells from pregnant women are more susceptible to infection with the Zika virus compared to white blood cells from non-pregnant women. We do this by collecting two tubes of blood from…
Estimate key transmission parameters of SARS-CoV-2 in Europe from observing within household virus spread and seroconversion of household members, and to characterize the views and experiences of households regarding perceptions, practices regarding…
The overall aim of this study is to assess the multidimensional health status of COVID-19 survivors one year post-infection using validated subjective and objective measures.
Primairy objective:- Identify causes of secondary deterioration or failure to improve after viral encephalitis by studying activation of the immune system and production of autoantibodies.Secondary Objectives are to:- Determine if the delayed…
A pilot study to understand the transmission dynamics of RSV in households and potential reduction of viral transmission.
We aim to characterize innate anti-viral defence responses in the upper airways of COPD patients.
Primary objectives:- To prospectively study and describe the aetiology, clinical management and clinical impact of atypical viral infections in immunocompromised patients in Europe- To assess the utility of metagenomics as a tool to support clinical…