95 results
1) to evaluate the effect of cART on markers of thrombophilia plasmalevels in hiv-infected patients2) to evaluate the long-term effect of cART on lipid spectrum3) to evaluate the incidence of venous thrombosis and cardiovascular events in hiv-…
Elucidation of the pathogenic role of cornea-infiltrating HSV-specific T-cells in HSK patients.
To investigate the prevalence and evolution of mucosal IgA and circulating IgA and IgG SARS-CoV-2 antibody titers and their relation to symptom severity and the presence of PCR-detectable (other) coronaviruses.
Our overall aim is to assess the seroprevalence of SARS-CoV-2 antibodies in an international population of pwCF and to examine associations between SARS-CoV-2 infection and clinical risk factors for infection, as well as subsequent clinical outcomes…
To characterize the phenotype, function and gene expression profiles of immune cells and hepatocytes in blood and liver of patients with chronic hepatitis D.
Generate prospective follow-up data to increase our understanding of this rare disease.
More knowledge on immunity to VZV in these patient groups is necessary to be able to design preventive strategies to VZV infections in the future. To reach these goals, the proposed study is divided into two parts. The first part aims to determine…
To gain insight in clinical, virological and immunological mechanisms and predictors of the eradication of HIV. To gain insight in the dynamics of the T cell HIV reservoir in which HIV is persisting. To gain insight in different levels of immune…
To study a cohort of HIV infected and HIV uninfected MSM and HIV infected heterosexuals who (subsequently) acquired HCV infection with a known date of HCV seroconversion:1. To identify the frequency, clinical consequences and determinants (viral and…
It is not known whether recurrent wheeze in preterm children is caused by RSV infection (serial hypothesis) or that RSV infection is the first indication of chronic airway morbidity that would develop anyway (parallel hypothesis). This study aims to…
1. Evaluation of neurocgnitive functioning in children with HIV in comparison with healthy siblings using questionnaires.2. Qualitative analysis of different determinants that play a role in school participation in children with HIV using interviews…
ALICE is a randomised controlled trial in Primary Care that aims to determine whether adding antiviral treatment to best usual primary care is effective in reducing time to return to usual daily activity and so the clinical and cost effectiveness of…
To determine ex vivo neutrophil functions following exposure to therapeutic antibodies targeting inhibitory receptors expressed by neutrophils from RSV bronchiolitis patients. A secondary aim is to study soluble inhibitory receptors (such as LAIR-1…
With this research we aim at gaining more insight into the reason for the fact that some individuals reconstitute well during cART whereas other do not. Also, we would like to investigate what mechanism is responsible for reconstituting the CD4 T-…
To study anti-SARS-CoV-2 antibody-mediated inflammatory responses by macrophages in individuals with obesity.