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To obtain insight whether skeletal muscle adaptations can explain post-exertional fatigue malaise in patients with PASC and ME/CFS, the present study will address the following objectives: Primary objectives:• To determine markers for skeletal…
The main objective of this trial will be to get a better insight in the influence of age and age-related changes by internal and external factors on vaccine-induced immune responses and gain knowledge on the trajectory of immune decline in older…
Primary research objectiveTo describe the recovery of physical and mental quality of life after a COVID19 infectionSecondary research objectives:1. Investigate the incidence of SARS-CoV2 re-infections during follow-up expressed in number of cases…
- To assess the in vitro memory T cell response to 20 therapeutic SARS-CoV-2 vaccine candidate synthetic long peptides (SLPs);- To assess the in vitro humoral immune response to 20 therapeutic SARS-CoV-2 vaccine candidate SLPs.
To identify correlations between immune changes at the cellular or molecular level in the serial FNAB and blood samples before and after withdrawal of treatment, and * in case of relapse - to identify correlations between the degree of immune…
Which determinants (risk exposure, symptoms, compliance with measures) are associated with a positive SARS-CoV-2 antibody test in inhabitants of the province of Limburg?
Primary objective* To determine the seroprevalence of SARS-CoV-2 neutralising antibodies in HCWs in Dutch hospitals.Secondary objectivesBaseline, all participants * To determine the seroprevalence of SARS-CoV-2 total antibodies in HCWs in Dutch…
Primary objectives * To establish the prevalence, disease spectrum and severity, clinical features, management, risk factors, spread and outcomes of novel 2019 coronavirus infection (SARS-CoV-2) in Hospital Care in selected European countries;* To…
To screen the immune repertoire of healthy volunteers for broadly reactive fusion-inhibiting antibodies directed against coronavirus S protein, including SARS-CoV-2 f and (if found) to isolate/clone and further characterize such antibodies with the…
To determine the frequency of R5-tropic N332+ viral isolates present within the latent reservoir while on suppressive ART.
The focus of the research is a cross-sectional comparison between the samples of fine needle liver aspirates of patients at different chronic HBV infection phases with the aim to identify correlates between intrahepatic immune changes at the…
Primary objective: To evaluate, in a cohort of non-tested individuals who reported flu-like symptoms during the COVID19 epidemic in the Netherlands (March-November), the seroprevalence of COVID19 in patients with an IMID, with or without…
Primary Objective: - To assess the effect of MMR-0 vaccination on the humoral immunity against measles 2 years (+/- 2 months) after MMR-2 vaccination.Secondary Objective(s): - Determine the effect of MMR-0 vaccination on the humoral immunity against…
To characterize the phenotype, function and gene expression profiles of immune cells and hepatocytes in blood and liver of patients with viral hepatitis before, during and after treatment with antivirals.
To identify genetic host factors associated with HCV susceptibility among HIV-infected MSM.
Primary objectives: 1. . To study prevalence of NASH in unselected HIV-monoinfected patients assessed by Fibro scan. Secondary objectives:2. To identify risk factors for NASH in HIV infected patients compared to HIV-positive patients without NASH. 3…