283 results
Primary* To characterize the dynamics of viral clearance (incl. viral cultures, qPCR, antigen clearance) following ensovibep administration * To characterize the serum pharmacokinetics of two single i.v. flat dose levels of ensovibep in patients…
Primary* To estimate the effect of NME combination therapies on inducing a functional cure over the control arm.Secondary * To characterize the efficacy profile of NME combination therapies.* To characterize the PD profile of NME combination…
Primary Objective:• To create a population pharmacokinetic model of SARS-COV-2 neutralizing antibodies as present in ConvP.• To create a population pharmacokinetic model of SARS-COV-2 neutralizing antibodies as present in Nanogam*plusSecondary…
The longitudinal assessment of the BAFi pyrimethamine and of the HDACi valproic acid on the HIV reservoir size in HIV patients on antiretroviral therapy.
* To assess the safety and tolerability of Ampligen administered intranasally in a dosing schedule for 13 days (7 doses) in healthy subjects.* To characterize the mucosal immune response following Ampligen administration over time.
PrimaryTo characterise the single and multiple dose to steady state pharmacokinetics of IV zanamivirin hospitalised neonates and infants under 6 months of age with influenza infection.SecondaryTo evaluate the safety and tolerability of IV zanamivir…
The primary objective is to assess the clinical efficacy of dapansutrile versus placebo in subjects presenting with moderate COVID-19 respiratory symptoms and evidence of early cytokine release syndrome.Secondary objectives are to assess:* Complete…
In this research study we will look whether in the blood of patients who were recently infected with the coronavirus (SARS-CoV-2), antibodies can be found that neutralise the virus. We will produce those antibodies. With the produced antibodies we…
This study has been transitioned to CTIS with ID 2024-514888-25-00 check the CTIS register for the current data. Objective: to provide proof of concept for the inhibition of HBx mediated cccDNA transcription by terbinafine, both as monotherapy and…
Primary:To demonstrate the non-inferior antiviral activity of CAB LA + RPV LA every two months compared to a BIK single tablet regimen administered once daily over 12 months in suppressed HIV-1 infected antiretroviral therapy (ART)-experienced…
To investigate the feasibility of measuring the oxygen saturation at home by pulse oximetry as added to usual (primary) care in patients with or at risk of cardiovascular risk who have moderate to severe symptoms of (presumably) COVID-19 as compared…
Primary ObjectiveTo determine if the humoral immune response of a single compared to a two dose COVID-19 vaccination regimen is non-inferior in paediatric subjects who are immunologically primed by natural infection. Secondary Objective(s) 1.To…
This study has been transitioned to CTIS with ID 2024-515487-31-00 check the CTIS register for the current data. The primary objective of this study is to describe the pharmacokinetics of antiretroviral agents, for which no or limited available…
The primary objective is to estimate product-specific vaccine effectiveness (VE) of the COVID-19 vaccines that are used in the Dutch national vaccination program against symptomatic SARS-CoV-2 infection by age and medical risk group at a time point…
Objectives: The primary objective of this study is to evaluate the effect of response to treatment (assessed by SVR12 status) on the long-term progression of liver disease in adults with chronic HCV GT1 infection who received treatment with ABT-450/…
To test whether monthly infusions (every four weeks) of intravenous Flebogamma® 5% DIF in a 1 year treatment period in PPS subjects are superior to placebo by assessing physical performance, as measured by 2MWD.For Stage 1, to select the optimal…
The objectives of this study are:1) Assessing the user-friendliness of a self-sampling technique.2) Assessing the quality of the self-collected sample (volume and composition).3) To estimate the degree of agreement between viral loads in the self-…
This study has two parts. The main objective of part 1 (in vivo) is todetermine changes in markers of oxidative stress in exhaled breath as a result of different short term oxygenation strategies (liberal versus conservative) . The main objective of…
Primary objectives: - To evaluate the effect of oral vitamin K2 supplementation on extrahepatic vitamin K status, as measured by circulating dp-ucMGP, during COVID-19 requiring hospital admission- To evaluate the effect of oral vitamin K2…
The aim of this research is to set up a human infection model for yellow fever with a reliable read-out measure for virus replication after vaccination, so that this model can be used in the future to investigate potential treatments for yellow…