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Switching to Tenofovir Alafenamide Fumarate or ABACavir in patients with Tenofovir Disoproxil Fumarate associated eGFR decline. A randomized clinical trial.

To study the renal safety when HIV patients with TDF related renal toxicity switch to TAF compared to the current practice of switching to ABC.

Generation of broadly neutralizing antibodies for the development of an enterovirus immunotherapy

Primary Objective: To isolate B-cells producing bNAbs against EVs from healthy human individuals and to generate bNAbs from these B-cells for the development of a novel EV immunotherapy. Secondary Objective(s): To further elucidate the humoral…

Influence of the acidic beverage cola on the absorption of the HCV agent velpatasvir in healthy volunteers being treated with the proton pump inhibitor omeprazole.

Primary objective:To assess the bioequivalence of single-dose velpatasvir administered as a fixed-dose combination of sofosbuvir/velpatasvir (SOF/VEL; Epclusa®) when given with cola + omeprazole 40mg (test 1/trt A) compared to velpatasvir…