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Detection of schistosoma CAA in travellers after high-risk water contact

Primary objective: to assess the UCP-LF CAA test in travellers with high-risk water contact as compared to routine diagnostics

Prestudy Optimizing Diagnosis of Community-Acquired Pneumonia

The objective of the standardized protocol is optimalizing the accuracy of the diagnosis (all-cause pneumonia, or serotype-specific pneumonia) during the 13-valent pneumococcal vaccin (13vPnC) study which will be performed in 2008. Additionaly, the…

Gene expression in sepsis and sterile sirs in pediatric patients after cardiac surgery

To differentiate between gene expression in sepsis and sterile sirs.

Establishing a Controlled Human Hookworm Infection Model at Leiden University Medical Center

Primary objective:To establish four healthy donors for future CHHI studies

Safety and protective efficacy of repeated controlled human Schistosoma mansoni Infection

Primary Objectives: - To determine the protective efficacy of repeated exposure to male Schistosoma mansoni (Sm) cercariae in healthy Schistosome-naïve volunteers based on CAA levels.- To determine the safety and tolerability of repeated exposure to…

Establishing a Female-only Controlled Human Schistosoma mansoni Infection Model: a safety and dose finding study (CoHSI2)

Primary Objective: - To investigate the safety, tolerability and attack rate of female Schistosoma mansoni cercariae in healthy Schistosome-naïve volunteers Exploratory Objectives: - To investigate the kinetics of circulating anodic antigen (CAA)…

Maintaining Controlled Human Hookworm Infection Model studies at Leiden University Medical Center

Primary objectives: • To establish two hookworm-infected donors to set up the controlled human hookworm infection model in Gabon • To study early-phase immune responses to hookworm exposure during the first four weeks after challengeExploratory…

Assessment of infection activity in travelers and migrants diagnosed with
chronic schistosomiasis: a multicentric prospective cohort study

To determine the proportion of travelers and migrants diagnosed with chronic schistosomiasis as per each centre*s routine assessment, who have active infection at presentation (as assessed and classified by composite reference standards integrating…

Repeated Controlled Human Hookworm Infection in Healthy Dutch Volunteers

Primary objective:* To determine the safety and tolerability of repeated infection of Necator americanus L3 larvae in healthy volunteersSecondary objectives:* To compare the variability in egg output after cumulative infection with 50, 100 and 150…

Establishing a Single-sex Controlled Human Schistosoma mansoni Infection Model: safety and dose finding

Primary objective: To investigate the safety, tolerability and infectivity of male Schistosoma mansoni cercariae in healthy Schistosoma-naïve volunteers. Exploratory objectives: To investigate the kinetics of controlled infection with male…

Immunisation, Treatment and Controlled Human Hookworm Infection

Primary objective:* To determine the protective efficacy of repeated short term exposure to hookworm infection Secondary objectives:1. To explore the immunological response after repeated hookworm infections2. To evaluate the safety of and number of…