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Establishing a Controlled Human Hookworm Infection Model at Leiden University Medical Center

Primary objective:To establish four healthy donors for future CHHI studies

Establishing a Female-only Controlled Human Schistosoma mansoni Infection Model: a safety and dose finding study (CoHSI2)

Primary Objective: - To investigate the safety, tolerability and attack rate of female Schistosoma mansoni cercariae in healthy Schistosome-naïve volunteers Exploratory Objectives: - To investigate the kinetics of circulating anodic antigen (CAA)…

Maintaining Controlled Human Hookworm Infection Model studies at Leiden University Medical Center

Primary objectives: • To establish two hookworm-infected donors to set up the controlled human hookworm infection model in Gabon • To study early-phase immune responses to hookworm exposure during the first four weeks after challengeExploratory…

Establishing a Single-sex Controlled Human Schistosoma mansoni Infection Model: safety and dose finding

Primary objective: To investigate the safety, tolerability and infectivity of male Schistosoma mansoni cercariae in healthy Schistosoma-naïve volunteers. Exploratory objectives: To investigate the kinetics of controlled infection with male…