Search for a trial

Psychological consequences of solid organ transplantation. A study among Dutch liver transplant recipients

This study will focus on the positive and negative psychological consequences of organ transplantation in Dutch organ transplant recipients. The study will describe on posttraumatic stress and posttraumatic growth after organ transplantation, their…

Pancreatitis of biliary origin, Optimal timiNg of CHOlecystectomy (PONCHO)

To compare the outcome of early laparoscopic cholecystectomy (<72 hrs after randomization) with interval laparoscopic cholecystectomy (25-30 days after randomization) after mild biliary pancreatitis.

Management and treatment of patients with a (previous) substance dependency and/or marginally housed patients with chronic hepatitis C: a prospective observational registry

To register the feasibility of treatment with peginterferon and ribavirin for chronic hepatitis C in (previous) substance users and other difficult to treat patients within the Project Active Testing.

Burden of ERCP;
Preferences for treatment of common bile duct stones

The aim of this study is: 1) to determine the burden of ERCP in patients undergoing ERCP (descriptive study) and 2) to determine patients preferences for treatment strategy of CBDS (Discrete Choice Experiments).

Non-invasive rapid assessment of non-alcoholic fatty liver
disease (NAFLD) using Magnetic Resonance Imaging with LiverMultiScan (RADIcAL)

Primary objective: To investigate whether the introduction of LiverMultiScan as a standardised diagnostic test for liver disease can prove a cost effective method in different EU territories.Secondary Objectives:- To investigate patient satisfaction…

Non-invasive diagnosis and treatment of neonatal jaundice in primary care

We will assess the (cost-)effectiveness of implementing two interventions in the birth centre setting:1. TcB measurement as a non-invasive screening tool to identify jaundice.2. Application of phototherapy in the birth centre.We hypothesise that…

The pre-post differences in nutritional intake, information needs, motivation, lifestyle, clinical outcomes and fatigue symptoms of MASLD patients, and their engagement and adherence to the serious game: a pilot study.

To determine the effect size of the difference in nutritional intake (carbohydrates, calories, fiber) of MASLD patients before and after playing the serious game. In addition, information provision, information needs, physical activity, response…

A care path for the detection of advanced NAFLD-fibrosis: the Nijmegen-Leiden-Amsterdam 2-tiered care path study

The aim of the study is to improve case finding of advanced cases of NAFLD (>=F3 fibrosis), whilst simultaneously reducing unnecessary referrals for mild cases (NAFLD-related complications, and to assess the cost-effectiveness of the…

Better assessment of neonatal jaundice at home (BEAT jaundice @ home)

The primary objective of the study is to assess the proportion of neonates with hyperbilirubinaemia necessitating treatment that is detected using universal TcB screening compared to using only visual inspection, while decreasing the number of heel…

Scrutinizing (in)efficient use of cholecystectomy: a randomized trial concerning variation in practice.

Current practice variation in selection of patients with gallbladder stones and abdominal complaints for cholecystectomy is not efficient. Here we evaluate stepwise selection for surgery to improve patient outcome and to reduce the number of…

Acute biliary Pancreatits: early ERC plus sphincterotomy versus Conservative treatment: the APEC trial, a randomized, superiority, assessor-blinded multicenter trial.

The objective of the study is to investigate whether early ERC plus ES in patients with suspected APB and a predicted severe disease course without cholangitis, lowers the incidence of a composite endpoint of mortality and severe morbidity. Major…