65 results
Primary Objective: * The feasibility of combining MRE and 1H-MRS in NAFLD to distinguish simple steatosis from NASH. Secondary Objective(s): * The influence of steatosis on MRE measurement* The influence of inflammation on MRE measurement
To calculate the repeatability and reproducibility of MRE stiffness measurements in the liver on a voxel-by-voxel basis.
To determine whether different MR-based imaging techniques and FibroScan can be used for the purpose of identifying and monitoring Gaucher Disease patients at high risk of developing disease related liver complications.
To demonstrate completeness of occlusion of the segmental portal branches after unilateral PVE by intraoperative portography. A secondary aim is to assess the perfusion of the liver after PVE on microvascular level by O2C and ICG clearance; and to…
To determine metabolites and natural occurring peptides in urine by mass spectrometry in patients with hepatocellular carcinoma. This study is designed as a validation study; in a smaller study a spectrum of metabolites and natural occurring…
Primary:- To determine default values of liver phosphorus metabolite ratios using 31P-MRS at 3.0T in healthy volunteers- To determine default values of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) in the liver using DTI-MRI at…
The primary objective is to explore the association between peripheral T-cell activation and apoptosis and hepatic fibrosis in various underlying liver diseases. Secondary objectives are 1) to investigate whether level of T cell activation and…
To study the effect of peginterferon alpha and ribavirin on spermatozoa
The primary objective is to confirm the diagnosis of biliary atresia by visualisation of the (remaining) biliary tract using fluorescence cholangiography.
The primary objective is to study if non-diabetic patients with biopsy-proven NASH have higher hepatic FDG-uptake as compared to non-diabetic patients with biopsy-proven non-inflammatory steatosis?Secondary Objectives are (1) to study the…
To assess the diagnostic accuracy of MR Elastography in detecting and monitoring different degrees of liver fibrosis compared to FibroScan and histopathology in patients with suspected chronic viral liver disease and non-alcoholic fatty liver…
The aim of this study is to evaluate the effect of supplementation of a high oral dose of omega-3 fatty acids on hepatic steatosis and glucose metabolism in morbidly obese patients undergoing laparoscopic Roux-Y gastric bypass surgery (LRYGBP).
Analysis of volatile organic compounds in exhaled air as a non-invasive biomarker for liver diseases
To identify VOC profiles in exhaled air that are unique for specific liver diseases.
This study aims to collect biochemical evidence for the pro-hemostatic capacity of DDAVP in patients with cirrhosis, in order to proceed towards a more rational clinical use of this drug.
Primary Objective:Validate the accuracy of:· MR Flow mapping in measuring PPG in patients with GoreTex®-covered TIPS as compared to the gold standard, portography.· MRA for establishing TIPS patency as compared to Doppler US and using invasive…
The aim of this study is to validate a protocol for ultrasonographic hepatic fat assessment, by means of Magnetic Resonance Imaging technique (MRI) as gold standard.
Validation of pre-operative H1-MRS at 3.0 Tesla for assessment of hepatic steatosis as a risk factor for postoperative morbidity and mortality after hepatectomy. Is there a close correlation between the 1H -MRS measurement of fat and the…
The aim of the study is to improve the diagnostic tools of spontaneous bacterial peritonitis.The primary aim is to evaluate the use of dipsticks as bedside diagnostics compared to the current standard polymorphonuclear leukocyte count in identifying…
Aim of this study is to assess the value of cholangioscopic directed biopsies versus brush cytology in differentiating between malignant and benign biliary strictures. Determination of tumor markers to improve early diagnosis of malignant biliary…
To investigate peripheral circulation in the hyperdynamic circulation of cirrhotic patients and its correlation with the Child-Pugh score.