33 results
Current practice variation in selection of patients with gallbladder stones and abdominal complaints for cholecystectomy is not efficient. Here we evaluate stepwise selection for surgery to improve patient outcome and to reduce the number of…
The objective of the study is to investigate whether early ERC plus ES in patients with suspected APB and a predicted severe disease course without cholangitis, lowers the incidence of a composite endpoint of mortality and severe morbidity. Major…
To compare the outcome of early laparoscopic cholecystectomy (<72 hrs after randomization) with interval laparoscopic cholecystectomy (25-30 days after randomization) after mild biliary pancreatitis.
The primary objective of this Registry is:• To assess the durability of sustained virologic response (SVR) following treatment in a Gilead-sponsored hepatitis C study.The secondary objectives of this Registry are:• To determine whether subsequent…
The primary objective of this Registry is:• To evaluate HCV viral sequences and the persistence or evolution of treatment emergent viral mutations in subjects who fail to achieve an SVR after treatment with a Gilead oral antiviral containing regimen…
Evaluate effects of one month alcohol abstinence in a healthy population of moderate drinkers.
Study of the phenotype and function of NK cells obtained from peripheral blood and liver of patients who are successfully being treated for at least 3-4 years for their chronic HBV infection with tenofovir in a flow-up study (METC nr. 2008-271).
To register the feasibility of treatment with peginterferon and ribavirin for chronic hepatitis C in (previous) substance users and other difficult to treat patients within the Project Active Testing.
To examine the genetic contribution to the mechanism of lapaquistat acetate induced hepatic abnormalities.
This study will focus on the positive and negative psychological consequences of organ transplantation in Dutch organ transplant recipients. The study will describe on posttraumatic stress and posttraumatic growth after organ transplantation, their…
We aim to develop a novel immunotherapy based on donor-derived exosomes that specifically suppress the anti-donor T-cell response after organ transplantation, while leaving overall immunity intact. The therapy targets both the direct and the…
Primary objective is to compare physical activity (time spent in moderate to vigorous activity and physical activity level) and exercise capacity (VO2 peak) in children after OLT with published data of healthy controls.Secondary objective is to…
To evaluate in detail the functionality of immune cells in blood in chronic HCV patients before, during and after treatment with ASV and DCV, in an IFN-free regimen.
The aim of this study is: 1) to determine the burden of ERCP in patients undergoing ERCP (descriptive study) and 2) to determine patients preferences for treatment strategy of CBDS (Discrete Choice Experiments).
Assessment of intra en inter reproducibility of 3.0 Tesla proton magnetic resonance spectroscopy in assessing hepatic steatosis. Reproducibility of visible peaks in water unsuppressed and suppressed MR spectra.
To study the correlation between histology and elastography in patients with elevated liver enzymes more than two times normal upper limit and the suspection of liver fibrosis or cirrhosis treated with MTX from the department Rheumatology and…
To evaluate in detail the functionality of immune cells in the liver and blood in chronic HCV patients before, during and after treatment with telaprevir, pegylated-IFN-alfa and ribavirin.
To identify correlations between immune changes at the cellular or molecular level in the serial FNAB and blood samples before and after withdrawal of treatment, and * in case of relapse - to identify correlations between the degree of immune…
To study phenotypic and functional characteristics of hepatic lymphocytes in patients with viral hepatitis or other liver related diseases.
The focus of the research is a cross-sectional comparison between the samples of fine needle liver aspirates of patients at different chronic HBV infection phases with the aim to identify correlates between intrahepatic immune changes at the…