21 results
To examine the genetic contribution to the mechanism of lapaquistat acetate induced hepatic abnormalities.
To evaluate in detail the functionality of immune cells in the liver and blood in chronic HCV patients before, during and after treatment with telaprevir, pegylated-IFN-alfa and ribavirin.
Assessment of intra en inter reproducibility of 3.0 Tesla proton magnetic resonance spectroscopy in assessing hepatic steatosis. Reproducibility of visible peaks in water unsuppressed and suppressed MR spectra.
To study the correlation between histology and elastography in patients with elevated liver enzymes more than two times normal upper limit and the suspection of liver fibrosis or cirrhosis treated with MTX from the department Rheumatology and…
The primary objective of this Registry is:• To evaluate HCV viral sequences and the persistence or evolution of treatment emergent viral mutations in subjects who fail to achieve an SVR after treatment with a Gilead oral antiviral containing regimen…
To quantify fructose that escapes the portal circulation and appears in the systemic circulation, by measuring serum fructose using ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) within 150 minutes following intake of…
The primary objective of this cohort study is to determine the prevalence of simple and progressed NAFLD in subjects at risk followed by the general practitioner The secondary objectives are:1. To study the factors linked to the development of…
To study phenotypic and functional characteristics of hepatic lymphocytes in patients with viral hepatitis or other liver related diseases.
Primary objectives: 1. . To study prevalence of NASH in unselected HIV-monoinfected patients assessed by Fibro scan. Secondary objectives:2. To identify risk factors for NASH in HIV infected patients compared to HIV-positive patients without NASH. 3…
Pilot study to evaluate whether frequencies of donor-specific Teff and Treg in blood differ between tolerant and non-tolerant LTx recipients. Furthermore, the mechanism of tolerance will be studied by characterization of T cells within the blood of…
Main objectives: To obtain true population-based prevalence and incidence figures, as well as insight in the natural history of PSC and PBC in The Netherlands.Secondary objectives: to determine risk factors correlated with PSC and PBC respectively,…
To characterize the immune response and gene expression profiles in blood of chronic HBV patients who present with a flare after treatment with antiviral therapy in order to be able to predict spontaneous resolution of flares in the future.
To identify correlations between immune changes at the cellular or molecular level in the serial FNAB and blood samples before and after withdrawal of treatment, and * in case of relapse - to identify correlations between the degree of immune…
The focus of the research is a cross-sectional comparison between the samples of fine needle liver aspirates of patients at different chronic HBV infection phases with the aim to identify correlates between intrahepatic immune changes at the…
To characterize the phenotype, function and gene expression profiles of immune cells and hepatocytes in blood and liver of patients with viral hepatitis before, during and after treatment with antivirals.
Primary objective is to compare physical activity (time spent in moderate to vigorous activity and physical activity level) and exercise capacity (VO2 peak) in children after OLT with published data of healthy controls.Secondary objective is to…
To evaluate in detail the functionality of immune cells in blood in chronic HCV patients before, during and after treatment with ASV and DCV, in an IFN-free regimen.
The primary objective of this Registry is:• To assess the durability of sustained virologic response (SVR) following treatment in a Gilead-sponsored hepatitis C study.The secondary objectives of this Registry are:• To determine whether subsequent…
We aim to develop a novel immunotherapy based on donor-derived exosomes that specifically suppress the anti-donor T-cell response after organ transplantation, while leaving overall immunity intact. The therapy targets both the direct and the…
Study of the phenotype and function of NK cells obtained from peripheral blood and liver of patients who are successfully being treated for at least 3-4 years for their chronic HBV infection with tenofovir in a flow-up study (METC nr. 2008-271).