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SINGLE-CELL RNA SEQUENCING OF LYMPHOCYTE SUBSETS AND CHOLANGIOCYTES IN NON-ENDSTAGE PSC PATIENTS

The aim of this project is to characterize the composition and activity of lymphocytes immune cell subsets and cholangiocytes in active inflammation in the central/extrahepatic bile ducts through surface markers and an in-depth transcriptomic…

Clinical application of annual Liver Multiscan and MRCP+ in Primary Sclerosing Cholangitis:

Main:The main objective is to explore the potential utility of MRCP+ and LMS in monitoring disease activity and early detection of worsening disease requiring endoscopic intervention. Secondary Objective(s): Assessment of mean, median, range and…

Fluorescence-guided resection Of Colorectal liver metastases Using SGM-101 and Indocyanine GREEN.

To assess the feasibility of simultaneous use of ICG and SGM-101 for intraoperative imaging of colorectal liver metastases.

FIT4Cirrhotics@Home: Effects of a home-based, bimodal lifestyle intervention in patients with liver cirrhosis awaiting orthotopic liver transplantation.

The primary objective of this study is to assess the individual patients* response to an exercise program on aerobic capacity at six weeks by measuring the VO2 at the VAT and VO2peak before and after a homebased bimodal lifestyle program in non-fit…

Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effects of EP547 in Subjects with Cholestatic Pruritus Due to Primary Biliary Cholangitis or Primary Sclerosing Cholangitis

Primary objective* To assess the efficacy of EP547 compared to placebo on pruritus as assessed by the Worst Itch Numeric Rating Scale (WI-NRS)Secondary* To assess the efficacy of EP547 compared to placebo on the following:* Pruritus-related quality…

Primary percutaneous stenting above the ampulla versus endoscopic drainage
for unresectable malignant hilar biliary obstruction.

To compare the efficacy of PPS above the ampulla to standard EBD in patients with MHBO who are ineligible for surgical resection.

Optimization of spleen VCTE examinations with FibroScan

Main objective : To develop a spleen examination dedicated to overweight or obese patients and assessits applicability.Secondary objectives :1. Develop a spleen exam dedicated to patients usually measured with the S+ probe and assess its…

Study of the natural history of patients with rare inherited metabolic diseases, optimal treatment and complications

(also see: C1. Protocol, page 9, paragraph 2)Primary: Creating a metabolic bio-database with body material of patients with inherited metabolic diseases, combined with clinical data.Secondary: Achieve better participation in national and…

The Clock thickens:
Morning or evening training for the treatment of NAFLD?

The aim of the study is to identify the effect of exercise timing on NAFLD. Additionally, we aim to increase the understanding of the exercise-related modulation of the metabolic and inflammatory processes causing NAFLD, including insulin resistance…

Endoscopic Ultrasound-Guided Portosystemic Pressure Gradient
Measurements vs. Transjugular Balloon Occlusion Measurement: A Multicenter EU
Study

The primary study objective is to evaluate the correlation of the calculated portosystemic pressure gradient (PPG) obtained by direct portal and hepatic pressure measurements with the EchoTip® systemic Pressure Gradient (EchoTip® InsightTM) and…

Non-Invasive Portal and Hepatic Vein Pressure Estimation: MRI-Guided Diagnostics for Chronic Liver Disease

The primary objective is to develop and validate non-invasive portal pressure measurement by MRI in patients with end-stage liverdisease (ESLD).

Very short-course versus standard course antibiotic therapy in patients with acute ChOlangitis after
adequate endoscopic BiliaRy drAinage (COBRA trial).

The primary objective is to investigate if a very short-course of antibiotics for cholangitis after adequate drainage is non-inferior with respect to clinical cure in comparison with a standard course of antibiotics.

Standardising care for hepatitis delta in the Netherlands

Generate prospective follow-up data to increase our understanding of this rare disease.