151 results
Aim of the preceding study is to explore the applicability and feasibility of a rehabilitation program for improvement of complaints of fatigue in liver transplant recipients.
To show whether an intake of 20g CLA per day has negative effects on liver and kidney function in healthy human volunteers.
Primary objectives : to investigate the safety and tolerability of multiple oral doses of JTK-652 administered for 14 days to healthy male subjectsSecondary objectives : tot determine the pharmacokinetics of multiple oral doses of JTK-652…
With this trial we want to compare both somatostatin analogues, octreotide and lanreotide, in one trial, so we can see whether there is a difference in effect on liver volume in patients with polycystic livers. Furthermore, we want to find the…
efficacy of lanreotide LAR in controling total liver volume in patients with hepatic cysts as a result of ADPKD or PCLD
The primary objective is to study the effect of a 16-week treatment with a PPAR-* agonist versus placebo on effectiveness of subsequent standard treatment with PEG-IFN and RBV, measured as SVR, in previously non-responders or relapsers with CHC…
To eassess the effect of a switch in immunosuppressive regimen and dosing regimen on renal function, blood pressure and laboratory parameters.To assess the effect on renal function, blood pressue and laboratory parameters of a switc from tacrolimus…
The primary objectives of this trial are the following:- to determine the dose dependency of the antiviral effect of TMC435350 during 1 week ofmonotherapy in treatment-naïve HCV-infected subjects;- to determine the dose dependency of the antiviral…
In this study we will examine the short-term effects of a single bout of physical activity on liver fat content. Research question: What are the short- term effects of a single bout of moderate physical activity on liver fat content?
To assess the bile acid composition of cystic bile and serum pharmacokinetics after a 3-week treatment with UDCA and to correlate pharmacokinetic parameter sof UDCA in bile and serum during steady state.To compare the composition of bile acids and…
The objective of this trial is to explore the efficacy, safety, tolerability, pharmacokinetics, and pharmacokinetic-pharmacodynamic relationships of telaprevir when administered as 750 mg q8h or 1125 mg q12h in combination with Peg IFN alfa2a (…
To evaluate the safety and tolerability of FFP104 in PBC subjects following repeat doses of FFP104
Primary Objective: To study whether CSWI+PCA provides similar analgesia after laparotomies for HPB conditions as compared to PCEA measured as the OBAS score, a composite endpoint composed of pain score, patient satisfaction and opioid related side…
To evaluate the effect of bezafibrate in cholestatic pruritus.
This is a Dutch multi-centre study that aims to complete patient accrual through national collaboration. Patients with resectable PHC will be randomized to undergo either EBD or PTBD. The objective of the study is to identify a difference in the…
• To study whether the degree of fibrosis/cirrhosis measured by non-invasive markers diminishes after SVR.• To study whether parameters of clinically significant important portal hypertension change after SVR.• To study patient reported outcomes…
In Part 1, a single dose of EYP001a or placebo (same formulation but without the active ingredient EYP001a) will be administered and a total of 6 dose levels of EYP001a will be investigated. The purpose of Part 1 is to investigate how safe EYP001a…
Primary Objective: To assess whether the current use and dosing in cirrhosis of anticoagulation is as effective in inhibiting ex vivo thrombin generation compared to the treatment of patients with competent liver function
To investigate the in vitro effect of both pro- and anticoagulation therapy on thrombin generation by Calibrated Automated Thrombography in plasma from patients with cirrhosis undergoing liver transplantation.
To assess the safety and effect of edoxaban in Chil-Pugh B cirrhosis.