61 results
Main objective: investigate the correlation between CAP-values with fat percentages found at 1H-MR Spectroscopy and steatosis grade at liver biopsy. Secondary objectives: investigate the reproducibility of CAP-measurements; investigate the…
To compare accumulation of liver fat (as measured using CAP) and liver fibrosis (as measured using fibroscan) between patients with quiescent and active inflammatory bowel disease
To investigate the correlation between the CAP-value measured with the FibroScan® device and liver fat percentage measured with 1H-MRS in a well-characterized cohort of obese children at risk of having fatty liver disease.
main objective: Investigate the prevalence of liver fibrosis according to TE values in children enrolled in a HPN-program. Secondary objectives: Investigate the correlation between TE values and ELF test score and APRI in children enrolled in a HPN-…
The aim of this study is to compare the image quality, diagnostic confidence and patient discomfort when using either positive (50 ml Télébrix Gastro + 950 ml water ) or negative 1000 ml water only in outpatients undergoing a contrast-enhanced…
Objectives: The objective of the study is to observe the sorbitol clearance and compare this to ICG clearance in different circumstances of normal and compromised liver blood flow.
Investigate whether *T1-mapping of the liver with the liver specific MRI contrast agent Gd-EOB-DTPA allows measurement of the change in liver function after ERCP treatment of a dominant stricture in PSC patients.
This study aims to collect biochemical evidence for the pro-hemostatic capacity of DDAVP in patients with cirrhosis, in order to proceed towards a more rational clinical use of this drug.
The aim of this study is to retrieve extra measurements by Nexfin and laboratory testing in the per- and postoperative period. Can the use of Nexfin contribute in the generation of meaningful data to get an idea of the hemodynamic state of the…
In the present study we aim to test the hypothesis that the reservoir of HEV in the Netherlands are animals that are bred for meat consumption. Therefore we want to compare the HEV seroprevalence in vegetarians and in people with a very low meat/…
The primary objective is to explore the association between peripheral T-cell activation and apoptosis and hepatic fibrosis in various underlying liver diseases. Secondary objectives are 1) to investigate whether level of T cell activation and…
The purpose of this study is to improve the diagnosis and management of hepatocellular adenoma.
Analysis of volatile organic compounds in exhaled air as a non-invasive biomarker for liver diseases
To identify VOC profiles in exhaled air that are unique for specific liver diseases.
The aim of this study is to evaluate the effect of supplementation of a high oral dose of omega-3 fatty acids on hepatic steatosis and glucose metabolism in morbidly obese patients undergoing laparoscopic Roux-Y gastric bypass surgery (LRYGBP).
To determine metabolites and natural occurring peptides in urine by mass spectrometry in patients with hepatocellular carcinoma. This study is designed as a validation study; in a smaller study a spectrum of metabolites and natural occurring…
To determine whether different MR-based imaging techniques and FibroScan can be used for the purpose of identifying and monitoring Gaucher Disease patients at high risk of developing disease related liver complications.
Primary:- To determine default values of liver phosphorus metabolite ratios using 31P-MRS at 3.0T in healthy volunteers- To determine default values of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) in the liver using DTI-MRI at…
To demonstrate completeness of occlusion of the segmental portal branches after unilateral PVE by intraoperative portography. A secondary aim is to assess the perfusion of the liver after PVE on microvascular level by O2C and ICG clearance; and to…
Main goal: In this non-invasive pilot study, we want to investigate whether these techniques can discriminate between healthy livers and livers with cirrhosis. For the new techniques to be applied as an alternative for biopsy, the output values of…
This study will focus on the positive and negative psychological consequences of organ transplantation in Dutch organ transplant recipients. The study will describe on posttraumatic stress and posttraumatic growth after organ transplantation, their…