29 results
The primary objective of this Registry is:• To assess the durability of sustained virologic response (SVR) following treatment in a Gilead-sponsored hepatitis C study.The secondary objectives of this Registry are:• To determine whether subsequent…
The primary objective of this Registry is:• To evaluate HCV viral sequences and the persistence or evolution of treatment emergent viral mutations in subjects who fail to achieve an SVR after treatment with a Gilead oral antiviral containing regimen…
Evaluate effects of one month alcohol abstinence in a healthy population of moderate drinkers.
Study of the phenotype and function of NK cells obtained from peripheral blood and liver of patients who are successfully being treated for at least 3-4 years for their chronic HBV infection with tenofovir in a flow-up study (METC nr. 2008-271).
To register the feasibility of treatment with peginterferon and ribavirin for chronic hepatitis C in (previous) substance users and other difficult to treat patients within the Project Active Testing.
To examine the genetic contribution to the mechanism of lapaquistat acetate induced hepatic abnormalities.
This study will focus on the positive and negative psychological consequences of organ transplantation in Dutch organ transplant recipients. The study will describe on posttraumatic stress and posttraumatic growth after organ transplantation, their…
We aim to develop a novel immunotherapy based on donor-derived exosomes that specifically suppress the anti-donor T-cell response after organ transplantation, while leaving overall immunity intact. The therapy targets both the direct and the…
Primary objective is to compare physical activity (time spent in moderate to vigorous activity and physical activity level) and exercise capacity (VO2 peak) in children after OLT with published data of healthy controls.Secondary objective is to…
To evaluate in detail the functionality of immune cells in blood in chronic HCV patients before, during and after treatment with ASV and DCV, in an IFN-free regimen.
Assessment of intra en inter reproducibility of 3.0 Tesla proton magnetic resonance spectroscopy in assessing hepatic steatosis. Reproducibility of visible peaks in water unsuppressed and suppressed MR spectra.
To study the correlation between histology and elastography in patients with elevated liver enzymes more than two times normal upper limit and the suspection of liver fibrosis or cirrhosis treated with MTX from the department Rheumatology and…
To evaluate in detail the functionality of immune cells in the liver and blood in chronic HCV patients before, during and after treatment with telaprevir, pegylated-IFN-alfa and ribavirin.
To identify correlations between immune changes at the cellular or molecular level in the serial FNAB and blood samples before and after withdrawal of treatment, and * in case of relapse - to identify correlations between the degree of immune…
To study phenotypic and functional characteristics of hepatic lymphocytes in patients with viral hepatitis or other liver related diseases.
The focus of the research is a cross-sectional comparison between the samples of fine needle liver aspirates of patients at different chronic HBV infection phases with the aim to identify correlates between intrahepatic immune changes at the…
Primary objective: To investigate whether the introduction of LiverMultiScan as a standardised diagnostic test for liver disease can prove a cost effective method in different EU territories.Secondary Objectives:- To investigate patient satisfaction…
Primary objectives: 1. . To study prevalence of NASH in unselected HIV-monoinfected patients assessed by Fibro scan. Secondary objectives:2. To identify risk factors for NASH in HIV infected patients compared to HIV-positive patients without NASH. 3…
Main objectives: To obtain true population-based prevalence and incidence figures, as well as insight in the natural history of PSC and PBC in The Netherlands.Secondary objectives: to determine risk factors correlated with PSC and PBC respectively,…
To characterize the phenotype, function and gene expression profiles of immune cells and hepatocytes in blood and liver of patients with viral hepatitis before, during and after treatment with antivirals.