16 results
To evaluate the feasibility, safety and potential efficacy of acupuncture in children with FC. The results of this study will be used to design a future randomized controlled trial (RCT).
The main objective of this study is to determine the maximum tolerated dose (MTD) of 5 fractions MRgRT for patients with AC following FLOT therapy. The secondary objectives are feasibility, non-dose limiting toxicity, oncological outcomes and to…
The main objective of this study is to determine the maximum tolerated dose (MTD) of 2-fraction boost MRI-guided radiotherapy (MRgRT) for patients with SCC following CROSS therapy. The secondary objectives are feasibility, non-dose limiting toxicity…
The primary objective is to investigate the concordance between the Endosign test and EGD by an expert endoscopist for detecting dysplasia and/or EAC in a high-risk category of ULSBE patients. Secondary objectives are to determine the acceptability…
The primary objective of the study is to assess the diagnostic performance of the endoscopist performing a MAGENTIQ-COLO CADx-assisted colonoscopy to classify polyps as diminutive (<=5mm) or non-diminutive (>5mm) compared to size…
Measurement of intestinal oxidation-reduction potential using a smart sensing ingestible and its relation to active UC and CRC.
In this study, we are looking at the effectiveness of following phase 3, the maintenance phase, of the Crohn's Disease Exclusion Diet (CDED) compared to normal diet (with or without standard maintenance treatment) in children and adults with…
Primary objective: To investigate the effects of fully inhibiting type 2 inflammation on esophageal mucosal barrier function and inflammation in adult EoE patients. Secondary objective: To evaluate the effect of type 2 inflammation and the IL4 /…
Primary objective: To establish a controlled human infection model for C. difficile which is safe, well tolerated and results in microbiological and clinical endpoint in ideally >=70% of volunteers. Secondary objectives:- Assess colonisation…
The primary objective is to evaluate the effect of continuing GLP-1 RA on gastric volume after standard preoperative fasting in patients using GLP-1 RA for >12 weeks. Additionally, we will evaluate the effect of withholding GLP-1 RA on…
The aim of this trial is to investigate the safety and efficacy of an adaptive anastomosis using the C-REX RectoAid Cath following elective anterior resection for sigmoid or proximal rectal cancer, or premalignant lesions not amenable tot endoscopic…
Primary: To compare the efficacy of epigenome-guided treatment selection to usual standard of care (SOC) treatment selection for inducing clinical remission and endoscopic response at Week 26 in participants with active CD.Secondary:-To explore the…
To identify and synthesise patient-specific neoantigen peptides from residual material of resected pancreatic cancer tissue, from the organoids established from the resected pancreatic cancer tissue (MEC-2021-0325) and from peripheral blood.
To compare L-MILP with R-MILP for benign and pre-malignant lesions of the pancreas in high-volume centers, regarding:1. Peri- and postoperative outcomes in terms of COMPOS-panc left score, for non-inferiority2. Total hospital-related costs, for…
Intra-arterial pressure measurements are currently the most promising tool to guide clinical decision making in patients with suspected CMI. Implementation of pressure measurements could result in major improvements in quality of life by tailoring…
The primary objective of the study is to determine the technical feasibility of ctDNA detection in small volumes of capillary blood. This will be investigated through determining the agreement between ctDNA measurements in venous (standard blood…