26 results
To explore the extent of inter- and intrafraction anatomical changes of the tumour and surrounding normal tissues, throughout the full course of treatment, and to subsequently assess the impact of these changes on the nominal planned dose. This…
Currently, there is no guideline for the treatment of perianal Crohn's fistulas. the aim of this study, in which surgical strategies (seton drainage and surgical closure with advancement plasty/LIFT) will be compared to medical treatment. We…
Objective: the use of autologous platelet rich plasma (PRP) as an adjunct to the staged mucosal advancement flap to achieve a better closure rate of high peri-anal fistula*s.
To address the hypothesis that a potato derived protease inhibitor cream significantly limits perianal dermatitis in patients after colorectal surgery.
Aim of the study is to get informed on the outcome of women treated in the MUMC for obstetric anal sphincter injury between 2005 and 2012. The controlgroup is matched for maternal age at delivery, parity, mode of delivery and child weigth.
To assess the potential benefit of pelvic floor therapy for anal fissure. Measured primarily in pain, measured by the VAS score. Secondary outcomes are healing rates and recurrence.
A new surgical device for the creation of compression anastomoses, the ColonRing*, which is nickel- titanium based, has been introduced. Safety and efficacy of the device have been established in previous clinical studies and the device has been…
Aim of the present study is to investigate whether LIFT or TAFR is the preferable treatment for high transsphincteric fistulas-in-ano of cryptoglandular origin.
In daily practice there are many treatment modalities for hemorrhoids available. Since many years the rubberband ligation is widly used. Recently there are also positive results reported of the artery ligation procedure. This research aims to…
The primary efficacy variable is if the TachoSil application was feasible. A feasible application implies that the entire TachoSil adhere, TachoSil covers at least 1 cm beyond the margins of the anastomosis line and if more TachoSil sponges are used…
With this study we aim to determine the feasibility of Smooth Seton placement in patients with perianal fistulas
To assess efficacy of INCMGA00012 in terms of the ORR in participants with locally advanced or metastatic SCAC who have progressed after platinum-based chemotherapy.
Efficacy of treatment with biofeedback assisted pelvic floor physiotherapy using electromyography (EMG) in patients with chronic anal fissure.
The objective of this study is to assess the long-term safety of linaclotide in pediatric participants with FC (total exposure with linaclotide for 24 weeks) or IBS-C (total exposure with linaclotide for 52 weeks) who have completed study…
The primary objective of this RCT is to compare the effectiveness of RBL, sutured mucopexy and haemorrhoidectomy regarding recurrence and patient-reported symptoms for recurrent grade 2 and 3 HD after at least 2 previous RBL treatments. Secondary…
This study investigates the two most commonly performed surgical procedures for treatment of grade III hemorrhoids. It aims to identify the best surgical treatment for this patient group considering quality of life.. Other outcomes measured are…
With this pilot study we aim to determine the feasibility and efficacy of the novel catheter set, the Semiflex Dome Catheter System, for vacuum therapy of perianal abscesses/sinuses and fistulas. The pilot study will consist of 2 parts. First, 10…
The primary objective of this exploratory proof of concept clinical investigation is to confirm bulb catheter*s performance in adults already using Navina Smart.The secondary objectives and endpoints are to evaluate bowel emptying performance of…
With this study we hope to improve the closure rate of perianal Crohn*s fistulas.