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Obstetric anal sphincter injury, a follow-up study on the long term outcome.

Aim of the study is to get informed on the outcome of women treated in the MUMC for obstetric anal sphincter injury between 2005 and 2012. The controlgroup is matched for maternal age at delivery, parity, mode of delivery and child weigth.

Pelvic floor therapy in the treatment of all anal fissures; a multicentre, randomized controlled trial

To assess the potential benefit of pelvic floor therapy for anal fissure. Measured primarily in pain, measured by the VAS score. Secondary outcomes are healing rates and recurrence.

COMpression anastomosis ring (CAR* 27/ColonRing*) Post maRketing Evaluation Study

A new surgical device for the creation of compression anastomoses, the ColonRing*, which is nickel- titanium based, has been introduced. Safety and efficacy of the device have been established in previous clinical studies and the device has been…

LITA trial: A randomized controlled trial of ligation of the intersphincteric fistula tract versus transanal advancement flap repair

Aim of the present study is to investigate whether LIFT or TAFR is the preferable treatment for high transsphincteric fistulas-in-ano of cryptoglandular origin.

Non-randomised,open, multi-center trial evaluating feasibility and safety of Tachosil application on a colorectal anastomosis

The primary efficacy variable is if the TachoSil application was feasible. A feasible application implies that the entire TachoSil adhere, TachoSil covers at least 1 cm beyond the margins of the anastomosis line and if more TachoSil sponges are used…

HEMARTY
Hemorrhoid Artery Minimalisation A Randomized Trial of a ligation Therapy
(Doppler guided HAL versus non-doppler guided HAL procedure)

To determine the cost effectiveness of Doppler located arterial ligation and the random plexus ligation procedure in comparing the long term effectiveness of haemorrhoid treatment with regard to disappearance of clinical symptoms.

The Anal Fistula Plug versus the fistulotomy for the treatment of low perianal fistulas

To compare the Anal Fistula Plug with the fistulotomy in the treatment of low perianal fistula.

The role of the Anal Fistula Plug combined with infliximab in the treatment of perianal fistula due to Crohn*s disease. -a randomised controlled trial-

To assess the value of the Anal Fistula Plug combined with the infliximab treatment in the treatment of patients with a chronic loose seton due to perianal Crohn*s disease in terms of success rate, continence, quality of life.

The Anal Fistula Plug versus the mucosal flap advancement
for the treatment of Anorectal Fistula

To compare the Anal Fistula Plug with the mucosal flap advancement in the treatment of high perianal fistula in terms of success rate, continence, postoperative pain and sick leave.

A prospective single-blinded randomized multi-center clinical trial comparing the clinical efficacy and patient acceptability of open selective haemorrhoidopexy with stapled haemorrhoidopexy

The purpose of this prospective randomised trial is 1) to compare short- and long-term efficacy of open selective haemorrhoidopexy with stapled haemorrhoidopexy; 2) to compare patients satisfaction between open and stapled haemorrhoidopexy.

Anal cooler for anal pain

to investigate the clinical effects of the Anal Cooler

Prospective randomised multicenter study comparing the outcome of rubberband ligation and artery ligation of the hemorrhoidal arteries in the treatment of grade II and III hemorrhoids.

In daily practice there are many treatment modalities for hemorrhoids available. Since many years the rubberband ligation is widly used. Recently there are also positive results reported of the artery ligation procedure. This research aims to…

Pilot Study of SuperSeton Placement in Patients with Perianal Fistulas

With this study we aim to determine the feasibility of SuperSeton placement in patients with perianal fistulas.

Use of platelet rich plasma(PRP) as an adjunct in the treatment of high peri-anal fistulas.

Objective: the use of autologous platelet rich plasma (PRP) as an adjunct to the staged mucosal advancement flap to achieve a better closure rate of high peri-anal fistula*s.

Longterm outcome of biological mesh closure of the pelvic floor after extralevator abdominoperineal resection for rectal cancer.

The aim of this study is to determine the cost-effectiveness of pelvic floor reconstruction using a biological mesh afterstandardized eAPR with neo-adjuvant (chemo)radiotherapy.

Pelvic Floor Physiotherapy in chronic anal fissure

Efficacy of treatment with biofeedback assisted pelvic floor physiotherapy using electromyography (EMG) in patients with chronic anal fissure.

Treatment of Perianal FIstulas in Crohn*s Disease: Surgical closure vs Anti-TNF

With this study we hope to improve the closure rate of perianal Crohn*s fistulas.

A Phase 2 Study of INCMGA00012 in Participants With Squamous Carcinoma of the Anal Canal Who Have Progressed Following Platinum-Based Chemotherapy

To assess efficacy of INCMGA00012 in terms of the ORR in participants with locally advanced or metastatic SCAC who have progressed after platinum-based chemotherapy.

Feasibility study of Smooth Seton placement in patients with perianal fistulas

With this study we aim to determine the feasibility of Smooth Seton placement in patients with perianal fistulas

Use of laser in the treatment of perianal fistulas
(Anorectale fistel laser studie = ArFiLaS)

Our hypothesis is that treatment of peri-anal fistula with laser ablation is associated with equal closure rates compared to current therapies. As secundairy outcome, quality of life, postoperative pain and incontinence will be assessed. The primary…