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Pilot study LumenR assisted ESD in rectal adenomas in the Netherlands

This study aims to assess the efficacy, safety and effectiveness of LumenR-assisted ESD for the treatment of large rectal adenomas. In addition, the learning curve for this technique in endoscopists with experience in standard ESD is assessed.

A prospective study stratifying patients to follow up intervals based on risk of recurrence post wide field colonic EMR.

To prospectively validate the SERT scoring system for adenoma recurrence rates around the EMR scar after WF-EMR with SCAR technique applied to the defect margin.

Complete polyp resection rate of colorectal polyps: long follow-up study

To compare the percentage of incompletely resected polyps during colonoscopy for polyps sized 1-4 mm, 5-9 or 10-20 mm.

Resection of mucosa of human colon or rectal tissue using a new endoscopic device, the SuMO (Sub Mucosal Operation) Tissue Access and Resection System

The SuMO System showed good results for mucosal resection in a porcine model. This study is developed to evaluate the feasibility and safety of the SuMO (submucosal operation) Access and Tissue Resection System in human colon and rectum tissue.

TRANSANAL ENDOSCOPIC MICROSURGERY VERSUS ENDOSCOPIC MUCOSAL RESECTION FOR LARGE RECTAL ADENOMAS

In a randomized trial we will compare the cost-effectiveness and cost-utility of TEM and EMR for the resection of large rectal adenomas.

A Phase III Randomized Open-Label Study of Single Agent Pembrolizumab vs. Physicians' Choice of Single Agent Docetaxel, Paclitaxel, or Irinotecan in Subjects with Advanced/Metastatic Adenocarcinoma and Squamous Cell Carcinoma of the Esophagus that have Progressed after First-Line Standard Therapy (KEYNOTE-181)

Primary:1) To compare OS in subjects with squamous cell carcinoma of the Esophagus.2) To compare OS in subjects with PD-L1 Combined Positive Score (CPS)*10%3) To compare OS in all subjectsSecondary:1) To evaluate the progression free survival (PFS)…

Multicenter, randomised controlled trial comparing endoscopic Mucosal resection (EMR) And endoscopic submucosal dissecTIon (ESD) for resection of Large Distal non-pedunculated colorectal Adenomas

The aim of this study is to perform a randomized comparison between ESD and EMR in large (>20 mm) distal non-pedunculated polyps in a Western population. We aim to compare both procedures with regard to recurrence rates and radical (R0)…

A Phase 1b/2, Multicenter, Open-label Basket Study Evaluating the Safety and Efficacy of Bemarituzumab Monotherapy in Solid Tumors with FGFR2b Overexpression

This study has been transitioned to CTIS with ID 2023-505455-44-00 check the CTIS register for the current data. Part 1 (phase 1b)Primary:• To observe the safety and tolerability of bemarituzumabSecondary:• To evaluate preliminary antitumor activity…