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A randomized double-blind placebo controlled trial to evaluate the value of a single bolus intravenous alfentanil in CT-colonography

Primary Objective: To evaluate whether a single intravenous alfentanil bolus (7.5 mcg/kg) has a clinically significant analgesic effect in clinical patients who undergo an elective CT-colonography compared to placebo. We have defined a clinically…

The influence of hyoscine N-butylbromide on colonoscopic polyp detection ratio

To investigate whether bowel relaxation, induced by administration of hyoscine N-butylbromide, improves the detection, removal and colllection of lcolonic polyps during colonoscopy

Comparsion of computed tomography colonography with magnetic resonance colonography for use in colorectal cancer screening.

To compare the sensitivity and specificity of MR colongraphy with that of CT colonography for the detection of colonic neoplasms, compared to colonoscopy as "gold standard".

Standard colonoscopy versus high-definition colonoscopy with/without I-scan functions in the detection of colorectal neoplasia: a randomized multicenter study

Assessment of the adenoma detection rate at colonoscopy using :A: Standard colonoscope B: High Definition colonoscope C: High Definition colonoscope with surface enhancementD: High Definition colonoscope with surface enhancement and Colon Mode

Feasibility, Multi-center prospective study of Check-Cap's P1 Capsule System in Patients eligible for CRC screening

To establish the safety and preliminary efficacy of Check-Cap*s P1 Capsule System in patients eligible for CRC screening

Small bowel surveillance in patients with Peutz-Jeghers syndrome: comparing MR enteroclysis with double balloon enteroscopy.

The aim of this prospective study is 1) to evaluate the diagnostic efficacy of DBE in comparison to MRE as surveillance technique of the small-bowel in PJS patients, 2) to analyze patient burden and quality of life with DBE and MRE, and 3) to…

Combined pan-chromoendoscopy and confocal endomicroscopy for the diagnosis of colorectal neoplasia in subjects at high-risk for colorectal cancer

Objective: Two issues will be addressed:i) does pan-colonic chromoendoscopy improve the diagnostic yield of colonic polyps (and in particular flat lesions) as compared to conventional colonoscopy?ii) does pan-colonic chomoendoscopy combined with…

Identification of DNA methylation markers for plasma-based detection of advanced colorectal adenomas.

Identify DNA methylation markers suitable for sensitive and specific plasma-based detection of advanced colorectal adenomas.

A phase 2 intervention study:
Detection of early esophageal neopastic lesions by quantified fluorescence molecular endoscopy using oral and topical administration of bevacizumab-800CW and cetuximab-800CW

Primary objectives:The primary objectives are to evaluate the feasibility of oral administration of bevacizumab-800CW and cetuximab-800CW for detection of neoplasia in BE patients compared to HD-WLE to shorten the qFME procedure and test whether…

Synergistic effect of G-Eye balloon for behind the folds visualization with artificial intelligence assisted polyp detection (Discovery system) on adenoma detection rate.
*Discovery III study*

The primary objective of this study is to compare the effect on ADR of combining balloon-assisted and CADe assisted colonoscopy, compared to CADe assisted colonoscopy only.Secondary objectives are to compare the effect of adding balloon-assisted to…

Discovery: Pentax* Computer-aided Detection to Improve Adenoma Detection in a Real-time Setting - The Discovery II Study. A randomized clinical trial.

The primary objective of the study is to compare the ADR between PCSC and CC in patients referred for diagnostic, screening (non-iFOBT based) or surveillance colonoscopy.Secondary objectives are the following:- To compare the polyp detection rate (…

Randomized Two Arm Multi-Center Study to Evaluate the Safety and Efficacy of the Use of Magentiq Eye's Automatic Polyp Detection System (ME-APDS) During Colonoscopy

• Evaluate the safety of ME-APDS in subjects during colonoscopy.• Assess the efficacy of ME-APDS - whether the use of the ME-APDS improves the Adenoma Per Colonoscopy APC when compared to conventional colonoscopy (CC). Thereby we aim to further…

Discovery: Pentax* Computer-aided Detection to Improve Adenoma Detection in a Real-time Setting - The Discovery I Study

The primary objective of this study is to evaluate the feasibility of the Pentax CADe-system during colonoscopy procedures in terms of the polyp detection rate (PDR). We hypothesize that the use of the Pentax CADe-system is feasible and enables…

Into the light: guided visualization of high-risk cancer precursor lesions

Research directionUntil now only the tumor has been part of the search for new molecular imaging targets. The associated microbial biofilm that is present on 89% of right-sided CRCs and conventional advanced adenomas (CAAs) has so far not been…

Visualization of a VEGF-targeted Near-Infrared Fluorescent Tracer in patients with Familial Adenomatous Polyposis during Fluorescence Endoscopy.
A single center pilot intervention study

The primary objective of this study is to determine the sensitivity of the fluorescent tracer bevacizumab-IRDye800CW using a NIR fluorescence endoscope ans spectroscopy probe in identifying adenomatous polyps during surveillance endoscopy in…

Prospective randomized trial to compare the clinical efficiency (Adenoma Detection Rate) of G-EYE(TM) HD Colonoscopy with Standard HD Colonoscopy

The aim of this study is to compare the additional diagnostic yield (adenoma detection rate) of G-EYE colonoscopy with that of standard high definition colonoscopy.

Trans-Oral Sampling as an alternative for Barrett Surveillance: Transitioning Across Different Sampling Modalities through Cross-Validation; .

To evaluate the consistency and diagnostic accuracy of risk profiles using genetic markers across three different sampling modalities: biopsy, brush sampling, and TOS.

Trans-Oral Sampling as an alternative Surveillance of Barrett*s Esophagus Pilot:
The TOSS pilot-study

to determine the number of sufficient quality samples obtained through the use of the Cytosponge, which could potentially serve as a substitute for endoscopic sampling.

Clarity for patients with a liver adenoma, without a liver biopsy.

The question of this project is: can we demonstrate and exclude exon 3 mutations in CTNNB1 by analyzing circulating DNA from patients with a liver adenoma? The work plan is as follows: we include patients with a liver adenoma of at least 3 cm in…

MAGENTIQ-COLO CSC study
Evaluation of the diagnostic performance of computer-aided polyp size classification of the MAGENTIQ-COLO during real-time colonoscopy

The primary objective of the study is to assess the diagnostic performance of the endoscopist performing a MAGENTIQ-COLO CADx-assisted colonoscopy to classify polyps as diminutive (<=5mm) or non-diminutive (>5mm) compared to size…