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Small bowel surveillance in patients with Peutz-Jeghers syndrome: comparing MR enteroclysis with double balloon enteroscopy.

The aim of this prospective study is 1) to evaluate the diagnostic efficacy of DBE in comparison to MRE as surveillance technique of the small-bowel in PJS patients, 2) to analyze patient burden and quality of life with DBE and MRE, and 3) to…

Visualization of a VEGF-targeted Near-Infrared Fluorescent Tracer in patients with Familial Adenomatous Polyposis during Fluorescence Endoscopy.
A single center pilot intervention study

The primary objective of this study is to determine the sensitivity of the fluorescent tracer bevacizumab-IRDye800CW using a NIR fluorescence endoscope ans spectroscopy probe in identifying adenomatous polyps during surveillance endoscopy in…

Predisposing genetic risk factors for Barrett*s Esophagus

Primary Objective: To identify variants in the humane genome that are associated with BE risk. Secondary Objective(s): We will collect information on BE length, complication of BE (dysplasia, ulcer, stricture or EAC), presence of esophagitis and…

Identifying genetic determinants of Familial Barrett*s esophagus and adenocarcinoma of the gastro-esophageal junction

The main goals of this study1) To determine the prevalence of BE among first degree relatives of index patients in families that fulfil criteria for familial BE/adenocarcinoma of the GEJ2) Collect tissues of the index patients and all first degree…

The influence of hyoscine N-butylbromide on colonoscopic polyp detection ratio

To investigate whether bowel relaxation, induced by administration of hyoscine N-butylbromide, improves the detection, removal and colllection of lcolonic polyps during colonoscopy

A randomized double-blind placebo controlled trial to evaluate the value of a single bolus intravenous alfentanil in CT-colonography

Primary Objective: To evaluate whether a single intravenous alfentanil bolus (7.5 mcg/kg) has a clinically significant analgesic effect in clinical patients who undergo an elective CT-colonography compared to placebo. We have defined a clinically…

Feasibility, Multi-center prospective study of Check-Cap's P1 Capsule System in Patients eligible for CRC screening

To establish the safety and preliminary efficacy of Check-Cap*s P1 Capsule System in patients eligible for CRC screening

The role of miRNAs in the biology of Barrett*s esophagus

The primary objective is to generate genome-wide miRNA profiles of patient material (tissue samples and blood). The secondary objectives are to compare miRNA expression profiles to investigate what role differences in miRNA expression have in the…

Standard colonoscopy versus high-definition colonoscopy with/without I-scan functions in the detection of colorectal neoplasia: a randomized multicenter study

Assessment of the adenoma detection rate at colonoscopy using :A: Standard colonoscope B: High Definition colonoscope C: High Definition colonoscope with surface enhancementD: High Definition colonoscope with surface enhancement and Colon Mode

Combined pan-chromoendoscopy and confocal endomicroscopy for the diagnosis of colorectal neoplasia in subjects at high-risk for colorectal cancer

Objective: Two issues will be addressed:i) does pan-colonic chromoendoscopy improve the diagnostic yield of colonic polyps (and in particular flat lesions) as compared to conventional colonoscopy?ii) does pan-colonic chomoendoscopy combined with…

Bone Mass in Patients with Familial Adenomatous Polyposis

To assess the skeletal health of FAP patients.

Comparsion of computed tomography colonography with magnetic resonance colonography for use in colorectal cancer screening.

To compare the sensitivity and specificity of MR colongraphy with that of CT colonography for the detection of colonic neoplasms, compared to colonoscopy as "gold standard".

Prospective randomized trial to compare the clinical efficiency (Adenoma Detection Rate) of G-EYE(TM) HD Colonoscopy with Standard HD Colonoscopy

The aim of this study is to compare the additional diagnostic yield (adenoma detection rate) of G-EYE colonoscopy with that of standard high definition colonoscopy.

Identification of DNA methylation markers for plasma-based detection of advanced colorectal adenomas.

Identify DNA methylation markers suitable for sensitive and specific plasma-based detection of advanced colorectal adenomas.

An exploration of intestinal bacterial biofilms in Lynch syndrome patients as disease markers for colorectal cancer

Lynch-related tumors mostly develop in the ascending right side of the colon (70-85%). Strikingly, it was recently discovered that dense bacterial biofilms and invasive bacteria occur in the colonic mucosa of 87% of right-sided colorectal cancer (…

Discovery: Pentax* Computer-aided Detection to Improve Adenoma Detection in a Real-time Setting - The Discovery II Study. A randomized clinical trial.

The primary objective of the study is to compare the ADR between PCSC and CC in patients referred for diagnostic, screening (non-iFOBT based) or surveillance colonoscopy.Secondary objectives are the following:- To compare the polyp detection rate (…

Randomized Two Arm Multi-Center Study to Evaluate the Safety and Efficacy of the Use of Magentiq Eye's Automatic Polyp Detection System (ME-APDS) During Colonoscopy

• Evaluate the safety of ME-APDS in subjects during colonoscopy.• Assess the efficacy of ME-APDS - whether the use of the ME-APDS improves the Adenoma Per Colonoscopy APC when compared to conventional colonoscopy (CC). Thereby we aim to further…

Trans-Oral Sampling as an alternative Surveillance of Barrett*s Esophagus Pilot:
The TOSS pilot-study

to determine the number of sufficient quality samples obtained through the use of the Cytosponge, which could potentially serve as a substitute for endoscopic sampling.

Trans-Oral Sampling as an alternative for Barrett Surveillance: Transitioning Across Different Sampling Modalities through Cross-Validation; .

To evaluate the consistency and diagnostic accuracy of risk profiles using genetic markers across three different sampling modalities: biopsy, brush sampling, and TOS.

A phase 2 intervention study:
Detection of early esophageal neopastic lesions by quantified fluorescence molecular endoscopy using oral and topical administration of bevacizumab-800CW and cetuximab-800CW

Primary objectives:The primary objectives are to evaluate the feasibility of oral administration of bevacizumab-800CW and cetuximab-800CW for detection of neoplasia in BE patients compared to HD-WLE to shorten the qFME procedure and test whether…