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The bilious bowel: the relation between bile and bowel in development of biliary atresia and liver fibrosis. An explorative study

To investigate the origin of BA we will assess which TLR(s) is/are activated. To test the hypothesis that during development of BA and associated liver fibrosis there is a *leaky gut* and/or a change in microbiome we will use human material to…

Recurrence rate of hiatal hernia repair with biomesh compared to repair without mesh * a double blinded, randomized, controlled trial.

The above mentioned literature shows that repair of a hiatal hernia using a mesh gives fewer recurrences than repair without mesh. However, there are few prospective randomized controlled trials that provide clear results about this. The most…

A Multicenter, Prospective, Single-Blind, Randomized, Controlled, Study of the Repair of Challenging Abdominal Wall Defects: Strattice TM in abdominal Wall Repair (StaR)

The primary objective of this clinical study is to compare the incidence of post-repair wound related complications, including hernia occurence/reccurence between challenging abdominal wall defects repaired with Strattice Reconstructive Tissue…

Gastroschisis: identification of hereditary and nonhereditary risk factors

1. To assess the prevalence of structural, and dysmorphological abnormalities in a cohort of patients with gastroschisis.2. To identify possible candidate genes for gastroschisis by analysing the genes involved in copy number abnormalities in…

Ghrelin levels in patients with ACNES (Anterior Cutaneous Nerve Entrapment Syndrome) and gastrointestinal complaints, loss of appetite and weight loss.

The aim of this study is to verify our theory of an association between ACNES and pseudovisceral symptoms. We hypothesize in this study that fasting ghrelin blood level in ACNES patients with pseudovisceral symptoms and weight loss is lowered in…

MARS study- Mesh Augmented Reinforcement of Abdominal Wall Suture Line in Patients Undergoing Midline Laparotomy to limit the Rate of Incisional Hernia ( IH) Occurrence

The purpose of this prospective, pivotal, multi-center, single-arm cohort, pre-market, investigational clinical study is to assess the safety and performance of Deternia* Self-Gripping Resorbable Mesh when used for suture line reinforcement after…

Randomized Controlled Trial of Laparoscopic Primary Diaphragm Repair with Sutures Alone versus Sutures Reinforced with Mesh for Hiatus Hernia: A Long-Term Follow-Up

To assess the recurrence of hiatal hernia five to ten years after repair using sutures versus sutures reinforced with non-absorbable mesh.

Randomized Controlled Trial of Laparoscopic Primary Crural Repair versus Primary Repair with Circular Bio-absorbable Hiatal Mesh Reinforcement in Hiatal Hernia Repair

To define the optimum laparoscopic hiatus hernia repair, ensuring long-term effect with minimal postoperative side effects.