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The bilious bowel: the relation between bile and bowel in development of biliary atresia and liver fibrosis. An explorative study

To investigate the origin of BA we will assess which TLR(s) is/are activated. To test the hypothesis that during development of BA and associated liver fibrosis there is a *leaky gut* and/or a change in microbiome we will use human material to…

Comparison of Cousin Biotech® Adhesix* versus conventional mesh in open anterior inguinal hernia repair: a Multi-centre, Randomised, Double-blinded, Controlled Clinical Trial.

We would like to conduct a multicentre randomised controlled clinical trial to compare the difference in early postoperative pain after unilateral primary inguinal hernia repair in males. The procedures will be performed in day surgery. Early…

Reinforcement of closure of stoma site

To assess whether a biological mesh (collagen tissue matrix) reduces the incidence of clinically detectable stoma closure site hernias at two years compared to standard closure techniques.

Prevention of Parastomal Hernias and Incisional Hernias in Old Stoma Wounds: a pilot Study

We would like to conduct a RCT to confirm the hernia prevention effect of a mesh, however in a slightly different position, with a different mesh and with all types of stomas. In addition, we want to measure the possible benefit in terms of quality…

Gastroschisis: identification of hereditary and nonhereditary risk factors

1. To assess the prevalence of structural, and dysmorphological abnormalities in a cohort of patients with gastroschisis.2. To identify possible candidate genes for gastroschisis by analysing the genes involved in copy number abnormalities in…

Prevent Trial;Prevention of parastomal hernia during construction of a colostomy by reinforcing the bowel wall with a polypropylene mesh. ;A multicentre randomized controlled trial.

Patients in whom a permanent (end) colostomy is created in (semi) elective setting are randomised between the placement of a polypropylene mesh during stoma creation and the classic method without a mesh. Primary aim: Does the use of a lightweight…

Ghrelin levels in patients with ACNES (Anterior Cutaneous Nerve Entrapment Syndrome) and gastrointestinal complaints, loss of appetite and weight loss.

The aim of this study is to verify our theory of an association between ACNES and pseudovisceral symptoms. We hypothesize in this study that fasting ghrelin blood level in ACNES patients with pseudovisceral symptoms and weight loss is lowered in…

PREventing Surgical Site occurrences using negative pressURE wound therapy

Primary Objective: Primary objective of this trial will be to determine whether iNPWT reduces the number of patients with clinically relevant* SSOs after (potentially) contaminated ventral hernia repair <30 days after surgery. *A SSO is…

Prevention of incisional hernias with prophylactic synthetic mesh placement during stoma reversal

The aim of this study is therefore to prospectively investigate whether prophylactic synthetic mesh placement reduces the rate of stomal site incisional hernias after stoma closure without increasing (infectious) complications.