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Pancreatitis of biliary origin, Optimal timiNg of CHOlecystectomy (PONCHO)

To compare the outcome of early laparoscopic cholecystectomy (<72 hrs after randomization) with interval laparoscopic cholecystectomy (25-30 days after randomization) after mild biliary pancreatitis.

Epithelial Ion Transport Defects in Pancreatitis: establishment of an organoid model

Primary: To evaluate the ability to culture PDEC organoids from pancreatic duct biopsies. Secondary: (i) To evaluate ion transport in PDEC organoids derived from pancreatitis patients. (ii) To evaluate the ability of duodenal organoids to mimic ion…

Prospective Multicenter Microbiota Study for Evaluation and Monitoring of Severe Acute Pancreatitis

1) To establish associations between microbiome profiles and disease severity in patients with acute pancreatitis. 2) To establish associations between specific microbial shifts and infectious complications in the subgroup of patients with…

Next generation sequencing in patients with pancreatic ductal adenocarcinoma (PAN-NGS).
A nationwide prospective, translational cohort study.

To determine the prevalence of actionable genetic alterations in PDAC patients <= 60 years old.

Acute biliary Pancreatits: early ERC plus sphincterotomy versus Conservative treatment: the APEC trial, a randomized, superiority, assessor-blinded multicenter trial.

The objective of the study is to investigate whether early ERC plus ES in patients with suspected APB and a predicted severe disease course without cholangitis, lowers the incidence of a composite endpoint of mortality and severe morbidity. Major…

Immunogenic Neoantigen Profiling in Pancreatic Cancer - IMPRINT

To identify and synthesise patient-specific neoantigen peptides from residual material of resected pancreatic cancer tissue, from the organoids established from the resected pancreatic cancer tissue (MEC-2021-0325) and from peripheral blood.