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Carbohydrate induced resilience of the gut microbiome after antibiotics use

The objective of this study is to investigate the potential of a dietary fiber, 2'-fucosyllactose (2'-FL), to improve gut microbiome resilience after antibiotics use.Furthermore it will also be investigated whether there is a link between…

Multicenter, semi-blinded, randomized, controlled, parallel arms clinical study on the performance of SGM-101, a fluorochrome-labeled anti-carcinoembryonic antigen (CEA) monoclonal antibody, for the delineation of primary and recurrent tumor and metastases in patients undergoing curative surgery for colorectal cancer.

The primary objective of this clinical trial is to assess the performance of SGM-101 in theintraoperative detection of resection margins and metastases in patients undergoing curativesurgery for colorectal cancer. SGM-101 will be administered as a…

Pharmacokinetics and Pharmacodynamic Biomarkers of Janus Kinase Inhibitor Therapy in Patients With Ulcerative Colitis (PROPHETIC Study)

The objectives of this study, in patients with moderately to severely active UC who are administered JAKi SOC therapy are to evaluate the following (ranked according to priority), both for JAKi as a class of drugs and for each individual JAKi:1.…

A double-blind, randomized, placebo-controlled, phase 2a study to evaluate the safety, tolerability, and pharmacodynamic (PD) effects of two infusions of escalating doses of TPM502 in adults diagnosed with celiac disease (CeD)

Main objective:To evaluate the safety and tolerability of two i.v. infusions of escalating doses of TPM502 in CeD patients.Secondary objectives:• To identify PD effects consistent with the induction of antigen-specific immune tolerance following the…

Safety and Viability of an E. coli Nissle Colibactin Knockout in Healthy Volunteers: A Randomised Controlled Safety Study

Assess the safety and tolerability of the EcNΔClbP strain relative to the EcN wildtype strain following a 1-week daily administration, through questionnaires, medical examination and measurement of inflammatory markers.

The effect of Eye Movement Desensitisation and Reprocessing (EMDR) on abdominal pain in patients with Irritable Bowel Syndrome (IBS).

Our goal is to investigate the effect of EMDR treatment on abdominal pain in patiënts with Irritable Bowel Syndrome. In addition we will investigate the effect of EMDR treatment on other IBS physical complaints and on patients' experienced…

The effect of galacto-oligosaccharides on gut complaints without medical diagnosis (e.g. bloating, constipation, diarrhea) in adult women

to assess the effect of 21 days of consumption of 5.5 g GOS powder on the gut comfort component score (based on 5 questions), as compared to a control group receiving maltodextrin (control product).

Initial Case Series with Exalt Single-Use Duodenoscope * Expanded User Experience

The objective of this study is to confirm procedural performance of the Exalt single-use duodenoscope in Endoscopic Retrograde Cholangiopancreatography (ERCP) or other duodenoscope-based procedures.

Improving constipation by stimulating fiber intake using personalized dietary advice

To investigate the effectiveness of personalized dietary advice (PDA) in reducing constipation-related complaints, by increasing dietary fiber intake in people with constipation.

Protein digestion and amino acid absorption in the aging gastrointestinal tract

To assess the effects of aging on protein digestion and amino acid absorption in healthy humans.

A Phase 1, Open-label, Single Intravenous Infusion Dose Study to Evaluate the Mass Balance, Pharmacokinetics, Metabolism, and Excretion of TAK-954 Containing Microtracer ([14C]-TAK-954)in Healthy Male Subjects

TAK-954 is an investigational drug which means that it has not yet been approved for use. The main purpose of this study is to understand how the body handles TAK-954 (how it is absorbed, processed by and removed from the body). TAK-954 will be…

A Multicenter Randomized Controlled Trial to Compare the Efficacy of End-ischemic Dual Hypothermic Oxygenated Perfusion with Standard Static Cold Storage of Liver Grafts Donated after Circulatory Death in Preventing Non-anastomotic Biliary Strictures after Transplantation

To study the efficacy of end-ischemic DHOPE in reducing the incidence of NAS within six months after controlled DCD (Maastricht category III) liver transplantation.

Modulation of small intestinal microbial composition and activity, systemic immune adaptation and blood transcriptional changes induced by 2-wks consumption with 2 fermented milk products; a randomized, exploratory, cross-over, double blind, controlled study in ileostomy patients

Rationale: to determine the small intestinal microbiota response in humans to dietary interventions for two consecutive weeks, and to relate this to parameters of intestinal barrier function and immune and metabolic responses in blood, as functional…

Stimulating fiber intake by personalized dietary advice

To investigate if a personalized dietary advice is more effective in increasing dietary fiber intake in the Dutch population than the general advice that is currently provided by the Netherlands Nutrition center and the Dutch Digestive Foundation (…

A Pivotal, Prospective, Randomized, Controlled, Multicenter Superiority Clinical Study Comparing Standard Anastomosis Closure Technique to Standard Closure Technique Plus Sylys Surgical Sealant.

- To evaluate the impact of the use of Sylys® Surgical Sealant as an adjunct to standard anastomosis closure techniques on anastomotic leak rate. - To evaluate the impact of the use of Sylys® Surgical Sealant on the overall number of anastomosis-…