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A Multicenter, Randomized, Double-blind, Placebo controlled Study of the Human Anti-TNF Monoclonal Antibody Adalimumab for the Induction of Clinical Remission in Subjects with Moderately to Severely Active Ulcerative Colitis.

To assess the efficacy and safety of adalimumab for the induction of clinical remission in subjects with moderately to severely active ulcerative colitis.

Laparoscopic adjustable gastric banding (LAGB) versus open vertical banded gastroplasty (VBG). 5-year follow-up study of a prospective randomized trial: clinical results and quality of life.

This study aims to describe the long-term results of a randomized trial comparing LAGB and VBG with regard to clinical results and quality of life.

Comparison of Two Expandable Endoprosthesis for Benign Esophageal Disease

The primary objective of this study is to compare the stent migration rate of two metal expandable stents in patients with benign esophageal conditions.The secondary objectives are:• To compare the technical outcome.• To compare the functional…

Combined intracutaneous and intraperitoneal anaesthesia for postoperative pain reduction after laparoscopic cholecystectomy

To analyse the effect of preoperative intracutaneous and intraperitoneal instillation of levobupivacaine on postoperative pain after laparoscopic cholecystectomy

Multicentre, controlled, randomised, investigator-blinded, comparative study of oral Mesalazine 4g per day Once daily versus 4g per day in Two divided doses in patients with active Ulcerative colitiS (MOTUS study)

Primary objective: To demonstrate that mesalazine po 4g per day once daily (QD.) is non-inferior to the reference regimen, mesalazine 4g per day in two divided doses (BID.) (2g x 2 per day), in patients with active ulcerative colitis treated for 8…

Enhancing the quality of life of patients with inflammatory bowel disease; a multicentre study investigating cognitive behavioral therapy

The primary objective is to investigate the short-term effectiveness of individual cognitive behavioral therapy in a Dutch sample of IBD patients on quality of life, cognitions, and attitudes.The secondary objective is to investigate the extent to…

The SphynX trail: a randomised clinical trial that compares the outcome of endoluminal fundoplication with EsophyX* to laparoscopic Nissen fundoplication for GERD

To compare the outcome of endoluminal fundoplication with Esophyx* to laparoscopic Nissen fundoplication for GERD in selected patient population.

Effect of the consumption of a fermented dairy product on constipation in children: a multi-centre randomized controlled trial.

To determine the clinical effect and tolerance of BA in children with functional constipation aged 3-16 years.

A Double-Blind, Placebo-Controlled, Randomized, Multiple Ascending Oral Dose Study to Investigate The Safety, Tolerability, Pharmacokinetics And Pharmacodynamics of JNJ-26070109 In Healthy Subjects

JNJ-2607019 is an investigational drug being developed for gastroesophageal reflux disease (GERD) to reduce the complaints of abdominal pain and heartburn in people with this disease. JNJ-26070109 inhibits the gastrin receptor in the stomach. The…

Bowel preparation for elective left-sided colonic surgery.

The objective of this study is to ascertain the best method of bowel preparation, prior to elective left-sided colonic surgery in terms of patient comfort and surgical efficacy. The occurrence of infections (wound, peritonitis) and anastomotic leaks…

A Randomized, Double-Blind, Placebo-Controlled Study in Healthy Male Subjects to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single Ascending Oral Doses of JNJ-26070109

JNJ-2607019 is an investigational drug being developed for gastroesophageal reflux disease (GERD) to reduce the complaints of abdominal pain and heartburn in people with this disease. JNJ-26070109 inhibits the gastrin receptor in the stomach. The…

An investigation of the Effect of Long-Term Electrical Stimulation on Esophageal Acid Exposure in Pediatric Patients with Gastroesophageal Reflux Disease (GERD)

Primary Objective: Therapeutic effect of electrical stimulation. Secondary Objective(s): (i) Side effects of electrical stimulation(ii) Effect on quality of life (iii) Effect of electrical stimulation on inflammatory and histologic parameters.

Virtual Reality as pain relief during colonoscopies - Psychological factors related with the effect of Virtual Reality during colonoscopies

Primary objective: to investigate which independent variables (gender, age, abdominal pain during previous month, previous abdominal surgery, fear, locus of control, coping and focused attention) were related to the patients which are able to…

Comparison of laparoscopic procedures with and without the aid the AutoLap system - a Robotic Camera Holder

The objective of this study is to evaluate the ability to reduce the number of OR personnel required while performing the following procedures: colon resections (right hemicolectomy, left hemicolectomy/sigmoid resection), anti-reflux/hiatal hernia…

A randomized trial comparing the CORTRAK system with the endoscopic technique for duodenal feeding tube placement

Compare the success rate of duodenal feeding tube placement using the CORTRAK system (DFT-C) with the endoscopic technique (DFT-E).

A phase III, randomized, placebo-controlled clinical trial to study the efficacy and safety of MK-0517/fosaprepitant and ondansetron versus ondansetron for the prevention of chemotherapy-induced nausea and vomiting (CINV) in pediatric subjects receiving emetogenic chemotherapy

The objective of the study is to evaluate the efficacy and safety of a single dose of fosaprepitant when administered concomitantly with ondansetron, with or without dexamethasone, in subjects birth to 17 years of age receiving emetogenic…

Efficacy of online cognitive behavioral therapy on symptoms and quality of life with irritable bowel syndrome.

Primary objective:Is guided online treatment, based on CGT with mindfull- and exposure exercises, with minimal patient contact, effective for IBS-patients as compared to a waiting list?Secondary objectives: Will the guided online treatment lead to…

AMC colorectal organoids biobank: a living biobank

The aim of this proposal is to test this concept using organoid cultures and biobanked material of colon cancer patients and use these cultures to develop novel therapies in particular for the CMS4 subtype, which has mesenchymal features, a dismal…

Hypothermic oxygenated perfusion (HOPE) of human liver grafts before transplantation - A multicenter, randomized controlled trial

The purpose of this study is, in a phase II randomized trial, to test a newly developed machine perfusion technique of human liver allografts before transplantation.

A MULTICENTRE, SAD, AND MAD CLINICAL TRIAL TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF IV TREATMENT OF CALY-002 IN HEALTHY SUBJECTS AND SUBJECTS WITH COELIAC DISEASE AND EOSINOPHILIC OESOPHAGITIS

The objectives of Part B of the study are as follows: Primary: To assess the safety and tolerability of CALY-002 following multiple ascending doses administered IV in subjects with coeliac disease (CeD). Secondary: (1) To characterise the PK of CALY…