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Differentiating simple from complex appendicitis in children before surgery: The Complex Appendicitis Tool (CAT)

1. Immunology and Pathology:To determine the immune response of patients with simple and complex appendicitis in order to identify markers which distinguish between simple and complex appendicitis.2.Clinical and Imaging:To analyze the differences in…

The role of the intestinal microbiome in enteric and systemic vaccine immune responses

Primary Objective: to investigate the role of the gut microbiota in RVV immune response Secondary Objectives: To investigate the role of the gut microbiota in tetanus and pneumococcal vaccine immune responses

Donor feces infusion for first episode of Clostridium difficile infection in patients at risk for recurrent infection

The primary objective of this study is to investigate whether FMT after antibiotic therapy is more effective than conventionalantibiotic therapy alone in patients with a first episode of CDI.

A randomized controlled multicenter trial of a five day course of oral colistin and neomycin followed by restoration of the gut microbiota using fecal transplantation to eradicate intestinal carriage of extended spectrum beta-lactamase or carbapenemase-producing Enterobacteriaceae in high-risk patients

The purpose of this study is to evaluate the efficacy of two antibiotics ( neomycin sulfate and colistin sulfate), followed by fecal bacteria therapy , to multidrug - resistant bacteria (E - ESBL and EPC) to be eradicated from the intestine.

Intraoperative assessment of microcirculation with Laparoscopic Laser Speckle Analysis (lapLASCA) in patients elected for colorectal surgery for prediction of anastomotic leakage in colorectal anastomoses.

Experimentally, develop a software algorithm to objectively assess the microcirculation quality of the colorectal wall, intraoperative, by laparoscopy to predict the probability of developing anastomotic leakage, with the intention to develop a…

The microbiome of Q Fever Fatigue Syndrome (QFS)

To characterize the interaction between the gut microbiome, related metabolites, immune function, and perceived complaints in QFS-patients, CFS-patients, and healthy individuals.

A multi-center, randomized, double-blind study to compare the efficacy and safety of cadazolid versus vancomycin in subjects with Clostridium difficile-associated diarrhea (CDAD).;and substuy protocol:;A multi-center sub-study to validate the CDAD-DaySyms (Clostridium difficile-associated diarrhea - Daily Symptoms) PRO in sub CDAD participating in study AC-061A301 or AC-061A302.

Primary objectiveTo determine whether the clinical response after 10-day oral administration of cadazolid is non-inferior to oral vancomycin in subjects with CDAD.Secondary objectivesTo determine whether oral administration of cadazolid for 10 days…

Transluminal Endoscopic step-up approach versus miNimally invasive SurgIcal step-up apprOach in patients with infected pancreatic Necrosis: TENSION, a randomized controlled parallel-group superiority multicenter trial. Dutch Pancreatitis Study Group.

To determine the effectiveness and, subsequently, the cost-effectiveness of a endoscopic transluminal step-up approach (ETD & ETN) versus a surgical step-up approach (PCD & VARD ,if not possible laparotomy) to improve clinical…

Effect of donor human milk on severe infections and mortality in VLBW infants, a double blind randomized controlled trial

To determine whether (supplemental) human donor milk has beneficial effects (in terms of reduction of infectious episodes and mortality) when compared to (supplemental) preterm formula during the first 10 days of life in VLBW infants. Amendement ESS…

Effect of Galacto-Oligosaccharides supplementation on amoxicillin-treated gut microbiota from healthy adults : a proof of principal study

To explore whether the promising effects of GOS supplementation on the composition and activity of gut microbiota from healthy adults as found by in-vitro, can also be observed in-vivo.

Seroprevalence of hepatitis E virus infections among vegetarians.

In the present study we aim to test the hypothesis that the reservoir of HEV in the Netherlands are animals that are bred for meat consumption. Therefore we want to compare the HEV seroprevalence in vegetarians and in people with a very low meat/…

Antibiotic treatment alone for children with acute appendicitis; a prospective cohort study part of the Antibiotic versus Primary Appendectomy for Children with acute appendicitis; the APAC trial.

1. What is the complication rate of the initial antibiotic treatment strategy for acute simple appendicitis (radiological proven) in children aged 7-17 years old?

Pancreatitis, verY earlY compared wiTH delayed start Of eNteral feeding (PYTHON) trial: a randomised controlled multicenter trial.

To investigate whether a very early start of EN (< 24 hrs after admission), as compared to selective delayed EN (> 72 hrs), will lead to a lower rate of infectious complications and mortality in patients with predicted severe AP.

Immune respons after inactivated oral cholera vaccination (Dukoral) in kidneytransplant recipients.
Mucosal immune response in ImmunoCompromised Host (MICH)

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Novel therapies for secretory diarrhea

This study aims to assess the efficacy and potency of newly developed small molecule inhibitors of the GC-C signaling pathway and of the CFTR chloride channel in native human intestinal tissue.

The role of persistent gastrointestinal viral infections in the development of
enteropathy in children with Common Variable Immunodeficiency and secundary immunodeficiencies

To describe the prevalence of enteropathogenic viruses in children with primary (CVID and CVID-like disease) and secundary immunodeficiencies and a potential relation between this prevalence and the development of auto-/allo-immune enteropathy.

A randomized, placebo-controlled, double blind volunteer study into the effect of milk ingredients on gastroenteritis caused by an attenuated E. coli.

We want to determine whether Lacprodan® PL-20 can effectively protect against enterotoxigenic E.coli induced travellers* diarrhea in humans. In the present double-blind, placebo-controlled, randomized parallel study, the effect of oral milk protein…

Ammonia detection in Helicobacter pylori infections with the Ammonia Breath Analyzer (ABA) demonstrator. A pilot study to investigate the clinical application of the ABA.

The aim of this study is to assess the change of ammonia exhaled in Helicobacter pylori (HP) positive patients compared with patients that are not HP infected after urea administration. In principle, in this pilot study, the results of Kearney et al…

A randomized, placebo-controlled, double blind human trial into the effect of Protecflor on gastroenteritis caused by attenuated E. Coli

We want to study whether consumption of Protecflor can improve the resistance of humans to intestinal ETEC infection. An important parameter of intestinal resistance is the so-called colonization resistance. The colonization resistance is inversely…

The effects of the synbiotic Ecologic 825/scFOS on intestinal barrier function and immune modulation

The primary objective of this study is to assess the effects of the symbiotic Ecologic 825/scFOS on intestinal epithelial permeability.This study has five secondary objectives:1. The first secondary objective of this study is to study the microbiota…