48 results
The aim of our study is to measure 1) the prevalence of signs of child abuse and neglect in children with functional defecation disorders, 2) whether signs of child abuse and neglect are more common in children with functional defecation disorders…
Primary:- To identify causal genetic variants and proteomes involved in achalasia and to study their relevanceSecundary:- To build-up a large scale harmonized biobank of achalasia patients, based on combining existing and new data from the European…
The aim of this project is to study the effect of nicotine gum chewing in the prevention or reduction of POI and reduction of opioid use on patients who underwent elective colorectal surgery, and evaluate its safety and possible adverse effects.
Determine the existence of a relation between GER and apnea and their underlying mechanisms, in infants *37 weeks * 12 months.
To identify genetic risk factors associated with GERD.
Idenification of new Hirschsprung's disease associated genes.
Our hypothesis is that the brain processing of rectal sensation is impaired in children with functional fecal incontinence, leading to reduced cerebral activity during rectal distension. We will perform a pilot study using fMRI in combination with…
The first aim of this study is to identify factors which predict an improvement of gastroesophageal reflux after gastric banding. The second aim is to assess the effect of gastric banding on gastroesophageal reflux after the operation.
Identification of the causative gene for CSBS.
We aim to investigate the association between reflux episodes and supragastric belches using the technique of combined HRM and impedance monitoring.
The aim of the present study is to identify genes associated with functional constipation in a homogeneous subgroup of children responding to sacral neuromodulation by performing whole exome sequencing in both children and their parents and to…
Key objective: the hypothesis that will be tested Our hypothesis is that the decreased oesophageal acid sensitivity is mediated by oesophageal permeability changes. Furthermore we hypothesize that the electrical tissue impedance of oesophageal…
To identify chromosomal regions associated with the GERD-phenotype in a large multigenerational family with multiple affected members. Subsequently these regions will be sequenced to detect causative gene(s). The second aim is to describe the…
Quantify inflammatory response (through IL-8 production) of bronchial (both commercial available cells and cultivated brushed infant cells) when exposing these to gastric juice from: hospitalized Infants, before and during PPI treatment and age…
Key objective: the hypothesis that will be tested:Our hypothesis is that the proximal oesophagus of patients with GORD is more sensitive to acid than the distal oesophagus, which is due to more pronounced mucosal integrity changes in the proximal…
Primary:To investigate the presence of disease-specific antimyenteric antibodies and to identify their target-antigen in patients with achalasia.Secondary:- To determine to what extent humoral autoimmunity is the etiological factor in idiopathic…
To investigate the underlying mechanisms of gastroesophageal reflux and gastroesophageal reflux symptoms in treated achalasia patients.
To obtain more information about the effects of capsaicin and cinnamaldehyde on the intestine, these substances will be infused directly in the duodenum. Hereafter, the permeability of the intestine, gallbladder motility and the effects on satiety…
The aim of the study is to compare magnesiumhydroxide and polyethylene glycol/electrolytes with regard to the prevention of constipation and side-effects in palliative care cancer patients starting with opioids.
To study the diversity and functionality of intestinal microbiota of patients with IBS over time in comparison with asymptomatic controls.