19 results
Main questions:1. What is the success rate of antireflux surgery in children (reflux control) measured by means of validated and standardised investigation techniques?2. What is the effect of antireflux surgery on gastro-esophageal motility/function…
The main objective of this study is to obtain normal values for high-resolution manometry. The second objective is to investigate the inter- and intra-individual variability of the measured parameters.
The aim of this study is to gain insight in the mechanisms that may be involved in the effects of plant sterol drinks on gastric emptying and gallbladder motility. In order to test this, we compare the different effects of the consumption of a plant…
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To investigate the influence of left and right lateral position on the onset of TLESRs and GER and the underlying mechanisms during and after a test meal in GERD patients compared to healthy controls.
The aim of the study is to assess the cost-effectiveness of implementation of tube feeding in hospitalized IBD patients.
To study the diversity and functionality of intestinal microbiota of patients with IBS over time in comparison with asymptomatic controls.
The aim of this study is to assess the compliance of the EGJ in patients with achalasia and to compare this to LES pressure and the dysphagia score. We hypothesize that compliance measurement of the EGJ by endoflip in achalasia can warrant us extra…
The study aims to investigate the effects of moderate ethanol drinking on the intestinal permeability and the tight junction complex. If there increase in the intestinal permeability, these effects will be investigated at molecular level.
Aim: Is the Bifidobacterium breve effective in the treatment of childhood constipation.
The aim of this study is to identify predictive factors for the outcome of gastro-esophageal disease after gastric banding. Another aim is to identify predictive factors for the development of dysphagia.
The aim of this study is to identify predictive factors for the outcome of gastro-esophageal reflux disease after gastric banding. Another aim is to identify predictive factors for the development of dysphagia.
Our Objective is to show that the administration of prokinectics leads to an altered position of the acid pocket scintigraphically, and it thereby changes the rate of postprandial acid reflux episodes.
We hypothesise that the increased permeability of the esophageal mucosa in GERD patients can be shown using confocal laser scanning fluorescence microscopy. This difference in esophageal permeability may prove a diagnosticum for patients without…
The primary objective of this study is to assess the effect of band placement and of different stages of band adjustment on the esophageal bolus transit time and clearance by using intra-esophageal high resolution manometry and impedance monitoring…
The first aim is to determine the amount of nocturnal reflux (reflux time / 24 h) in obese subjects compared to normal weight subjects. Secondary objectives are to identify possible mechanisms which cause nocturnal reflux in this patient group and…
The main objective of this study is to investigate whether HRM is able to predict bolus transport of solids and liquids in the oesophagus as adequately as the gold standard, i.e. videofluoroscopy.
To investigate a) the functional role of chloride secretion in constipated adults (Ussing chamber studies) and b) inventory possible aberrancies in in situ ClC-2/ CFTR expression levels by immuno-histochemistry staining techniques.
Aim of the present study is to set up a large cohort of IBS patients in order to identify different disease characteristics as well as aetiological and pathophysiological factors in (sub)groups of patients with this heterogeneous disorder. Various…