400 results
The goal of this pilot study is to calculate the sensitivity and specificity for discriminating tumour and benign tissues in vivo in colorectal cancer patients based on optical spectroscopy measurements. The secondary goal of this study is to…
The pilot study will focus completely on testing of the quality of the CCE procedure as intended in the screening trial. The main study parameters are feasibility and logistical shortcomings, efficacy of bowel preparation and understandability of…
The ICAN research question is: What is the effectiveness of an intrathoracic compared to a cervical esophagogastric anastomosis after (hybrid) minimally invasive esophagectomy in terms of anastomotic leakage, morbidity, quality of life and costs?
The current study is designed to determine the most optimal treatment regimen for Barrett*s esophagus with early neoplasia, using the Self Sizing RFA balloon. In this study we will compare the standard ablation regimen (1x-clean-1x) with a…
1.We seek a better understanding of the mechanism of response / non-response to the above treatment in patients with esophageal carcinoma.2.To investigate whether there is a correlation between the CSC percentage and outcome in esophageal cancer…
Establishment of an image-guided brachytherapy procedure that is feasible for a multicenter randomized trial
The aim is to determine the effectiveness of adjuvant HIPEC using oxaliplatin following a curative resection of a pT4 or intra-abdominally perforated colon cancer in preventing the development of PC in comparison to the standard adjuvant systemic…
To evaluate the benefits, risks and costs of laparoscopic gastrectomy as an alternative to open gastrectomy (gold standard) as treatment for gastric cancer in a Western population.
The primary aim of this study is to describe the relationship of I/R injury during hepatic resection and hepatic microcirculation. The hypothesis is that the microcirculatory alterations concerning the total vessel density (TVD), microvascular flow…
There is evidence however that abdominal wall blocks, such as TAP blocks, could help managing the postoperative pain, but covering the visceral pain is not possible with this technique. It is not even clear to date which component of pain, the…
This study investigates the impact of a goal directed nutritional support protocol on sarcopenia in oncological patients undergoing an esophagectomy and secondary the incidence of anastomotic leakage and pneumonia, surgical infection and lenght of…
1. To investigate tumor-interaction properties and tumor-education of platelets from patients with GI cancers. 2. To expand our knowledge of phosphatase expressions pattern in GI cancers
1.The main objective of this study is to explore and clarify the preferences, barriers and facilitators for pre-operative exercise participation for elderly treated for colorectal cancer and their social network. 2. To identify the barriers and…
The global aim of this project is to determine the immunophenotype-genotype interactions of PC. The novel insights in the molecular genomic and immunological profile of the tumor tissue and metastases are expected to help determine the immune…
To evaluate the feasibility, accuracy and safety of sentinel node navigation surgery (scintigraphy combined with indocyanin green and near-infrared technology) in patients with early esophageal carcinoma.
To assess the safety and feasibility of HIPEC and CS in Western patients with peritoneal metastases of gastric cancer, in terms of morbidity and mortality. Secondary objective is to determine the effect on survival and recurrence.
Primary: To estimate the antitumor activity (assessed as overall response rate) of PDR001 as a single agent in patients with non-functional neuro-endocrine tumors (NET).Secondary: To estimate efficacy (duration of response) of PDR001. Safety and…
Primary objective:- To develop a patient-specific adaptive radiotherapy planning strategy using MRI with more precise target coverage and critical organ sparing by safely reducing treatment margins for resectable esophageal cancer irradiation.…
Within the framework of the CARNAVAL 2.0 project, this technique is applied to a larger group of 30 patients by multiple surgeons. The primary goal of the study is to determine the oncologic resection rate with a tumour-clear resection margin and…
The aim of this trial is to investigate the safety and efficacy of an adaptive anastomosis using the C-REX RectoAid Cath following elective anterior resection for sigmoid or proximal rectal cancer, or premalignant lesions not amenable tot endoscopic…