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Minimally invasive versus open pancreatoduodenectomy

The objective of the LEOPARD-2 trial is to assess the safety of MIPD versus OPD and after that to assess the time to functional recovery of MIPD versus OPD for symptomatic benign, premalignant or malignant peri-ampullary disease.

Laparoscopic versus open distal pancreatectomy for symptomatic benign, premalignant and malignant disease

To determine whether time to functional recovery is shorter after LDP than after ODP for symptomatic benign, premalignant and malignant disease of the distal pancreas in an enhanced recovery setting.

Improving practicality of radiofrequency ablation for eradication of Barrett*s mucosa: a randomized trial comparing two different treatment regimens for focal ablation using the HALO90 System

To develop a simplified HALO90 ablation protocol at the same energy level and with compared efficacy and safety as the current protocol.

Prospective randomized comparison of EMR versus EMR followed by photodynamic therapy for the treatment of early barrett's cancer.

In this project we will evaluate the added value of PDT after complete EMR in patients with prior HGD and EC in Barrett*s esophagus.

Improving practicality of radiofrequency ablation for eradication of Barrett*s mucosa: a randomized trial comparing two different treatment regimens for circumferential ablation using the HALO360 System

The aim of the study is to develop a shorter, less technical demanding and therefore less uncomfortable for the patient, procedure for the HALO360 treatment of Barrett's esophagus with early neoplasie, high-grade or low-grade dysplasia, without…

Minimally invasive versus open pancreato-duodenectomy for pancreatic and peri-ampullary neoplasm (DIPLOMA-2): an international multicenter patient-blinded randomized controlled trial

The aim of DIPLOMA-2 is to compare MIPD with OPD regarding post-operative complications (non-inferiority) and time to functional recovery (superiority) for pancreatic and peri-ampullary neoplasm in high-volume centers in an enhanced recovery setting…