194 results
To evaluate the efficacy of Enterocutaneous fistula ( ECF) repair using the Biodesign enterocutaneous fistula plug ( Cook Medical).The primary objective of this study is to determine the feasibility, tolerance and primary technical success rate of…
This is a feasibility study of the Balloon-based Focal Cryoablation System to assess safety and performance in patients with a Barretts esophagus
Primary:- To determine the MTD and/or a recommended phase II dose (RP2D) of BYL719 when administered orally in combination with imatinib 400 mg q.d.Secondary:- Assess the safety and tolerability profile of imatinib and BYL719 administered in…
The goal of this study is to compare the efficacy and safety of the Wallflex stent to the Egis stent.
The aim of the clinical trial is to evaluate Hybrid-APC as a thermal ablation therapy for the treatment of BE following preceded endoscopic resection (ER) or as a primary therapy for neoplasia that are initially not detectable using high resolution…
This pilot study will evaluate the feasibility of endoscopic guided placement of gold markers in rectal cancer patients including:- Technical success of fiducial marker placement by (EUS guided) endoscopy- Visibility of fiducial markers on MRI and…
The primary objective of the study is to confirm that at least 1 or more doses of telotristat etiprate compared to placebo is effective in reducing the change from baseline in the number of daily bowel movements (BMs) averaged over the 12-week…
Primary objective:- to study the safety, tolerability and feasibility of gastrectomy combined with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) after neoadjuvant systemic chemotherapy as primary treatment option for…
The main objective is to investigate the effects of perioperative nutrition on postoperative ileus and anastomotic leakage in patients undergoing colorectal surgery
To compare the efficacy of P-SNN to EUS-CGN with regard to decreasing chronic malignant pain in patients with inoperable intra-abdominal malignancies.
Since imatinib easily and rapidly dissolves at pH 5.5 or less, a lack of gastric acid secretion might be causing the decreased exposure in the patients that underwent major gastrectomy. Therefore we would like to study if the exposure to imatinib in…
To perform a pilot study to evaluate safety and efficacy of using a covered self-expandable metallic stent for transluminal endoscopic drainage of a pancreatic fluid collection.
The study will collect data related to symptoms of recurrent biliary stent obstruction requiring reintervention, adverse events, and a variety of important secondary endpoints including technical success and time to symptomatic recurrent biliary…
Primary Study Objective: To evaluate the effect of telotristat etiprate versus placebo over the double-blind portion of the study on the incidence of treatment-emergent adverse events (TEAEs)
This study will evaluate the efficacy of the CbFAS with the optimal safe dose on the conversion of Barrett's epithelium to healthy squamous cell epithelium in a larger cohort. Furthermore, the device performance of the improved CbFAS will be…
The aim of the study is to assess the efficacy and safety of the self-sizing RFA ballon for eradication of Barrett's mucosa with low-grade, high-grade and early neoplasia
To improve the local tumor control rate by escalating the radiation dose in definitive chemoradiotherapy for patients with locally irresectable or medically inoperable carcinoma of the esophagus or gastric junction without distant metastases (stage…
The aim of this study is to assess the safety and efficacy of the new CaptivatorTM EMR kit.
Optimize the protocol for linear amplification of tumour RNA extracted from FNA's under GMP conditions.
Primary Objective• For Arms A, B, and C: Determine the overall response rate (RR) of EZN-2208 for two distinct cohorts of patients with mCRC- Patients with mutated K-RAS tumors (Arm A)- Patients with wild-type K-RAS tumors (Arms B and C)• For Arms B…