15 results
Determine if there are immunological or patient characteristics in UC patients that predict the endoscopic response on Vedolizumab treatment.
The aim of our study is to assess 1) The influence of once daily versus twice daily use of 5-ASA medication on adherence 2) The influence of the use of apps on adherence in ulcerative colitis patients on 5-ASA
To study potential abnormal functioning of the bile salt-FXR-FGF19 axis in patients with clinically quiescent Crohn*s colitis.
Identifying subsets of Crohn's disease (CD) at risk for poor outcomes is a priority in pediatric CD research. Having the ability to predict patients more likely to relapse, to be refractory to therapy or to develop complications may enable…
The present study aims to extent the sparse knowledge on sexual function in IBD by 1) examining the prevalence of sexual problems in men and women with IBD (including Crohn*s disease and ulcerative colitis), 2) comparing this with the prevalence of…
To study potential abnormal functioning of the bile salt-FXR-FGF19 axis in patients with clinically quiescent Crohn*s colitis.
We propose to assess the accuracy of MRI in a multicenter diagnostic accuracy study that will include a consecutive series of patients from the general population with suspected acute appendicitis. Patient acceptance and cost-effectiveness will also…
Evaluation of the incidence of liver enzyme abnormalities and hepatic steatosis in all type 2 diabetes mellitus patients (about n=1500) treated at the outpatient clinic internal medicine of the St Lucas Andreas Hospital
The objective of this project is to find out if TPMT genotyping prior to thiopurine use is cost-effective in patients with inflammatory bowel disease (IBD) in need of immune suppression.
1. Primary objective: 1.2 To assess the correlation of protein profiles between intestinal tissue and serum in patients with IBD2. Secondary Objectives:2.1 To identify the source matrix that has the highest chance to yield clinically relevant IBD…
Primary Objective: To investigate the relationship between disease activity and iron deficiency (i.e. absolute and functional ID combined) in children with IBD. Secondary Objectives: 1.To establish the prevalence of iron deficiency (both absolute…
To investigate the effect of oral curcumin supplementation on different clinical parameters and the gut microbiota composition in patients with diabetes type II, inflammatory bowel disorders (both ulcerative colitis and Crohn*s disease in remission…
Primary Objectives: To unravel the immunological characteristics of postoperative recurrent CD and study the immunological changes in the IL-23 pathway following treatment with biological agents.Secondary Objectives:To study clinical, endoscopic and…
To determine the long-term outcome after necrotizing enterocolitis during neonatal life, regarding (pain) sensitivity, sensory processing, behaviour, executive function, scar satisfaction (in surgically treated NEC patients), and (health-related)…
The main aim of this project is to obtain a better control and treatment of immune-mediated diseases by exploring the universe of microenvironment imposed tissue signatures and their correlates in liquid biopsies.