337 results
The evaluation of the safety and feasibilty of the Photopill capsule treatment in patients with Ulcerative Proctitis
The aim of our study is to assess 1) The influence of once daily versus twice daily use of 5-ASA medication on adherence 2) The influence of the use of apps on adherence in ulcerative colitis patients on 5-ASA
To assess the safety of lengthening the adalimumab dosing interval from 2 to 3 weeks, in patients with Crohn*s disease or ulcerative colitis in long term (6 months) remission.
The primary objective of this efficacy and safety study is to demonstrate that tight control of disease activity using stringent criteria based on CDAI, hs-CRP, fecal Calprotectin, and corticosteroid use improves the rate of mucosal healing 48 weeks…
Main objective: To validate novel biomarkers that can predict (non-)response to anti-TNF induction treatment in pediatric and adult IBD patients.Secondary objectives: To accurately describe pharmacokinetics of IFX and ADA in pediatric and adult IBD…
Aim of this prospective study is to investigate the relation between non-trough serum IFX levels (4 and 6 weeks after infusion) and IFX trough levels (8 weeks after infusion) in patients with Crohn*s disease
To ex vivo assess the difference in effect of administration of NSAIDs, PPISs and SSRIs on the paracellular permeability of colon biopsies (i.e. change in trans-epithelial electrical resistance) between active, remission and non-MC patients, using…
The overall aim of this study is to assess the feasibility of implementing MRE for use in evaluating fibrosis in patients with Crohn*s Disease (CD) in a multicenter setting.The primary objective for this study is to evaluate *gain of enhancement* as…
The aim of the study is to gain more insight in the course of intestinal oxygenation, urinary I-FABP concentration, and plasma Citrulline levels (as markers for intestinal damage and recovery) after NEC in relation to time to full enteral feeding…
This study aims to provide a comprehensive assessment of global coagulation parameters in patients with ASC both in hospital and up to 12 weeks after discharge. The results will help define the period at risk for VTE and inform the rationale for…
The primary objective is the determination of faecal reference values of calprotectin, elastase and alpha-1-antitrypsin after RYGBP.
To assess the safety of lengthening the adalimumab dosing interval from 2 to 3 weeks, in patients with Crohn*s disease or ulcerative colitis in long term (6 months) remission.
Primary ObjectiveThe primary objective of this study is to assess whether high ADA serum levels lead to more side effects compared to therapeutic ADA levels in CD and UC patients who are in clinical and biochemical remission.Secondary ObjectiveThe…
Primary: To demonstrate that a liquid Neocate product (elemental nutrition) study decreased esophageal eosinophil count to less than 15 eosinophils per high-power field in adult patients with eosinophilic esophagitis.Secondary: To study the effect…
To show that in eosinophilic oesophagitis gastro-oesophageal reflux-induced epithelial barrier dysfunction facilitates passage of food-antigens through the epithelial barrier and subsequent increased exposure of antigens by dendritic cells activates…
To study MRI of the small bowel and colon in determining disease activity in patients with Crohn*s disease.
To determine the association between shLAIR-1/ hLAIR-2 levels in urine samples and clinical and endoscopic disease activity in patients with UC and CD
In a dose escalation study we will determine the safety and preliminary efficacy of allogeneic bmMSCs in the induction of response for active fistulizing CD.
Primary objectives1. What is the effect of stopping mesalazine in the maintenance setting of patients with quiescent CD?2. Can subgroups of CD patients, for example based on prior treatment (medical vs. surgical), localization of disease, disease…
The aim of our project is in-depth characterization of the microbiota components both adjacent to and within the mucosa in patients with IBD, by applying novel high-throughput analysis technology in a global description strategy approach.…