337 results
Primary: Safety and tolerability. Secondary: Effectiveness, quality of life, healthcare resource utilisation, work productivity.
1.1 Safety To evaluate the safety of long-term exposure with AMG 827 in subjects with Crohn*s disease 1.2 Efficacy * To evaluate the efficacy of AMG 827 as measured by the Harvey-Bradshaw Index (HBI) and the Crohn*s Disease Activity Index (CDAI)* To…
Study the very long-term efficacy (regarding reflux control) of antireflux surgery in children with severe GERD.
The primary objective is to assess the feasibility and accuracy of dynamic contrast enhanced MRI in diagnosing UC or CD in children as compared to endoscopy and abdominal ultrasound.The secondary objective is to assess the feasibility of dynamic…
To study potential abnormal functioning of the bile salt-FXR-FGF19 axis in patients with clinically quiescent Crohn*s colitis.
Setup method for detection of STAT3 phosphorylation in human blood derived from patients with various chronic inflammatory diseases.Test the effect of new compounds on this phosphorylation process.
Primary: to analyze serum samples of adult EoE patients for IgE reactivity to recombinant allergens of common foods.Secondary: to demonstrate the presence of ILC2 in periferal blood of adult patients with eosinophilic esophagitis Tertiary: To store…
zie K1
The overall objective of this study is an improvement in (early) diagnosis of NEC and its life-threatening complications, thus to be able to detect children who are *at risk* for NEC and its complications as early as possible. To this end we will as…
In this study we will explore the examination with the second generation Pillcam capsule (PCCE 2) in patients with Crohn's disease. Crohn's patients with symptomps that need an endoscopy according to the treating physisian, will be asked…
Aim of this prospective study is to determine (temporal changes in) the intestinal microbiota in faecal specimens and microbiota adhering to the intestinal mucosa using bacterial DNA-based profiling methods.
Identifying subsets of Crohn's disease (CD) at risk for poor outcomes is a priority in pediatric CD research. Having the ability to predict patients more likely to relapse, to be refractory to therapy or to develop complications may enable…
Primary: We hypothesize that in eosinophilic esophagitis gastro-esophageal reflux-induced epithelial barrier dysfunction facilitates passage of food-antigens through the epithelial barrier and subsequent increased exposure of antigens by dendritic…
The main objective is to validate WBC scintigraphy as a sensitive tool to measure and quantify inflammatory load in different severities of UC.The secondary objectives are to explore whether other disease activity markers, like serum C-reactive…
To determine the percentage of patients with nodular regenerative hyperplasia of the liver after at least 1 year of combination therapy of allopurinol and low dose AZA or MP and to compare this with the reported findings of 6TG induced NRH
Early detecting of dysplasia and adenocarcinoma in patients with long excisting crohn's disease.
To examine cellular damage, intestinal barrier function loss, activation of the Complement system and inflammatory alterations induced by ischemia and reperfusion of the human small and large intestine.Second, we aim to study the consequences of…
The present study aims to extent the sparse knowledge on sexual function in IBD by 1) examining the prevalence of sexual problems in men and women with IBD (including Crohn*s disease and ulcerative colitis), 2) comparing this with the prevalence of…
Evaluate the benefits, risks and costs of early surgical intervention as an alternative to current step-up practice for CP.
To develop a method to determine Infliximab in feces