157 results
To identify pathogenic bacterial biofilms in UC-patients with and without neoplasia in tandem with host factors such as barrier defects and carcinogenic pathway activation in a prospective cohort study.
The aim is to investigate the feasibility of DBS from finger prick for measuring infliximab drug levels and ATIs compared with the results of venepuncture serum sample measurements. As a secondary objective, measurements of albumin and CRP will also…
To determine the correlation between concetrations of inflextra/ infliximab as measured using finger prick blood and lateral-flow assay and using venous blood and the standard sanquin ELISA.
Primary Objective: Identification of rare variants in candidate genes and regulatory elements in pediatric IBD patients. Secondary Objective(s): To determine the functional consequences of identified genetic variants in IBD, we will correlate…
The primary aim of the current proposal is to get a better understanding of how CeD risk genes contribute to disease aetiology. To achieve this, we will apply a holistic approach in which we will study the behaviour of immune cells and the…
to investigate the course of the pancreatic enzymes (serum amylase, serum lipase and urinary amylase) related to the course and stage of acute pancreatitis and thereby calculating the diagnostic accuracy of each pancreatic enzyme for acute…
Primary Objective: 1. Determine if assessment of mucosal and serological immunological characteristics in combination with clinical indicators of disease behaviour and response to therapy can identify immune-based phenotypes with implications for…
To compare accumulation of liver fat (as measured using CAP) and liver fibrosis (as measured using fibroscan) between patients with quiescent and active inflammatory bowel disease
To study the effectiveness of gut-directed hypnotherapy in the treatment of IBS-like symptoms in patients with inflammatory bowel disease.
ObjectiveTo identify biomarkers for CAL in drain fluid and serum, in addition to RT-PCR for E. faecalis, that increase specificity and positive predictive value.
Primary Objectives: - To test the feasibility of culturing patient-derived Barrett*s esophagus organoids- To test pharmacological and chemotherapeutical agents in vitro on the cultured organoidsSecondary Objectives: - To create a small Biobank (of…
To investigate associations between IBD severity, ASCA titer, microbiota composition and C. albicans strains present in feces.
The primary objective is to assess environmental, hygiene-related risk factors for MC. Secondary objectives are the difference between the CC and LC subpopulation regarding hygiene-related risk factors, living area as potential risk factor and the…
Primary objectives:to describe the composition of intestinal microbiota in the course of pediatric IBD-patients by IS-proto describe the composition of intestinal microbiota of apparently healthy children, aged 4-17 years, by IS-pro Secondary…
The aim of this pilot study is to assess whether the cerebral metabolic changes in RA patients, are also present in CD patients with active disease and fatigue. The influence of chronic inflammation on cerebral metabolism in CD patients will be…
The main goal of this pilot study is to test feasibility of the present commercially available near-infrared fluorescence cholangiography (NIRFC) laparoscopic device during the laparoscopic cholecystectomy.
Aim of the present study is to characterize esophageal epithelial damage in NERD, EE and healthy controls by analysis of epithelial integrity, immunohistochemical markers of epithelial damage and histological changes of esophageal epithelium.
The overall objectives of this proposal are to develop two indices capable of measuring intestinal damage, and, separately, inflammatory disease activity in Pediatric Crohn's disease by means of Magnetic Resonance Imaging with Enterography…
The aim of the present study is to increase our understanding of the cost effectivity and the pathophysiology underlying the beneficial effect of autologous SCT. We will investigate the immunological mechanisms involved in the (re)induction of…
The primary objective of our study is to determine the efficacy and safety of top-down IFX treatment in moderate-to-severe pediatric CD.Secundary objectives are determination of PK data and predictors of response to IFX in pediatric CD.