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Paediatric pelvic physiotherapy added to conventional treatment of functional constipation in children in primary care.

The primary objective is to study the effect of paediatric pelvic physiotherapy in addition to conventional therapy on the number of patients with treatment success in children aged 4-17 years presenting in primary care with functional constipation…

The effect of a potato based low-osmolaric glucose polymer drink on gastric distress and running performance*

To investigate whether two newly developed, potato based LOPG drinks with a different osmolarity and volume taken before exercise, differently affect gastric distress after both a short and long term exercise, running performance, and the rate of…

Adalimumab for the treatment of perianal fistulas in Crohnâ¤*s disease more effective alone or combined to ciprofloxacin (ADAFI study)

To assess whether a combination of ciprofloxacin and adalimumab is more effective than adalimumab alone.

Effectiveness of probiotics in the treatment of children with chronic abdominal pain and small intestinal bacterial overgrowth. A randomized placebo-controlled trial.

The aim of this study is to find a succesful treatment for chronic abdominal pain and small intestinal bacterial overgrowth in children and at the same time improve the quality of life of these children. A second aim is to reduce the hospital visits…

THE EFFECT OF PROBIOTICS ON
THE FREQUENCY AND INTENSITY OF MIGRAINE ATTACKS
AND INTESTINAL PERMEABILITY - A PLACEBO-CONTROLLED TRIAL

To test whether probiotics, as adjuvant therapy, can reduce incidence and severity of migraine attacks by reducing intestinal permeability.

Colonic lavage prior to colonoscopy: comparison between different preparations.

Comparison of three cleansing solutions for bowel preparation prior to colonoscopy.

Valvuloplasty as alternative to Toupet fundoplication for the minimal invasive treatment of gastroesophageal reflux disease: a randomized controlled trial

This monocenter randomized controlled trial aims to compare postoperative outcomes of a laparoscopic valvuloplasty with a Toupet fundoplication in patients with GERD with a maximum hiatal hernia of 3cm. In addition, an economic evaluation of the new…

A Multicenter Randomized Parallel Group Phase III Study Comparing the Bowel Cleansing Efficacy, Safety and Tolerability of NER1006 (a Low Volume Bowel Cleansing Solution) versus a Sodium Picosulfate and Magnesium Salt (SP+MS) Solution Using a Day Before-Only Dosing Regimen in Adults

Primary Objectives: To evaluate the overall bowel cleansing efficacy and the *Excellent plus Good* cleansing rate in the colon ascendens of a 1-day day before-only split-dosing regimen with NER1006 compared to a 1-day day before-only split-dosing…

Tailored treatment of functional dyspepsia with nortriptyline: a multi-center double-blind placebo-controlled trial (TENDER)

Aim: To investigate the efficacy of nortriptyline in FD patients with a predicted CYP2D6 extensive metabolizer phenotype. Nortriptyline is a second generation TCA with significantly fewer anticholinergic side effects compared to the first generation…

In vivo effects of amylase trypsin inhibitors from wheat in the human gut: proof of cause of non-coeliac wheat sensitivity in irritable bowel syndrome?

We aim to perform a proof-of-concept study to assess the effect of ATIs on the intestinal barrier and immune function in healthy volunteers. We hypothesise that the ATIs either directly affect the intestinal barrier function, or indirectly by…

A Multi-centre, Randomized, Placebo-Controlled, Efficacy Study of Prebiotic Galacto-oligosaccharides on Gastrointestinal Symptom Severity in Patients with Irritable Bowel Syndrome

Primary Objective:To establish the efficacy of treatment with Bimuno on total IBS symptom severity in patients with IBSSecondary Objectives:To assess efficacy of treatment with Bimuno on (I) abdominal pain, (II) bloating, (III) global IBS…

The PROFUN study: PROtein Fermentation UNraveled - Exploring the relationship between digestibility and metabolite production.

The primary objectives of this study are:1) To investigate the feasibility of the GISMO GEN1 System to monitor biomarkers in the gastrointestinal tract by studying the ingestible transit time, data coverage, participant experience, and serious…

The effect of non-invasive transauricular vagus nerve stimulation on upper gastrointestinal motility in healthy individuals

To study the impact of tVNS on gut motor function, in particular with regards to its potential to induce phase III contractions in the upper GI tract, in healthy subjects.

A Phase 2/3, Multicenter, Randomized, Double-Blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of AK002 in Adult and Adolescent Subjects with Active Eosinophilic Esophagitis

To evaluate the efficacy of AK002 in adult and adolescent subjects with active EoE when compared to placebo, efficacy endpoints will be co-primary:1) The proportion of subjects who achieve a peak esophageal intraepithelial count of <=6…

Clinical Efficacy of Transcutaneous Auricular Vagal Nerve Stimulation in Irritable Bowel Syndrome and the potential predictive role for the Vagal-Autonomic Neurosignature

Primary objective: To study the clinical efficacy of tVNS for the improvement of abdominal pain in patients with IBS, as measured by the responder rates based on IBS symptom severity score (IBS-SSS) over an 8-week time period. Secondary objectives:…