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A Multicenter, Open-Label Study to Evaluate the Long Term Efficacy, Safety, and Tolerability of Repeated Administration of Adalimumab in Subjects with Crohn's Disease

The primary objective of this study is to evaluate the long-term efficacy, safety, and tolerability of repeated administration of adalimumab in subjects with Crohn's disease (CD) who participated in and successfully completed Study M14-115.The…

A Phase 2a Open-label Study to Evaluate Prediction of Response to Golimumab Using a
Transcriptomic Profile in Subjects with Moderately to Severely Active Ulcerative Colitis

OBJECTIVES AND HYPOTHESIS Primary ObjectiveThe primary objective is to evaluate the accuracy of the length-109 probe set panel in predicting mucosal healing (ie, improvement in the endoscopic appearance of the mucosa) at Week 6, as measured by the…

The influence of omeprazole and pantoprazole on the platelet reactivity and inhibition of platelet aggregration of clopidogrel.

To study the influence of omeprazole and pantoprazole on the platelet reactivity index and the inhibition of platelet aggregation by clopidogrel.

Functional abdominal pain (FAP) within the context of internalizing disorders in childhood; A randomized controlled cognitive-behavioural family intervention.

We hypothesize that cognitive behavioural family intervention will be more effective compared to standard treatment in regard to the perception of FAP and resolution of co morbid internalizing psychopathology.

Esophagal evaluation after cryo-ablation of AF

The objective of the study is to evaluate whether esophagal lesions are created by cryo-ballon technique for AF ablation, and to compare this with a group of patients undergoing radiofrequency catheter ablation of AF.