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Medical assessment of adverse health outcomes in Dutch childhood cancer survivors; a nationwide project; SKION LATER Q2008 onderzoek:
Hyposalivation in long-term survivors of pediatric cancers following different treatment regiments.

* To estimate the prevalence of hyposalivation and xerostomia in pediatric cancer survivors treated with different cancer regimens (e.g., H&N RT, TBI, CT, or those who developed cGVHD following allogeneic stem cell transplantation).* To…

The effect of INhaled Glycopyrronium bromide on Excessive Sialorrhea and Drooling in Parkinson disease: a dose finding study

The primary objective is to investigate the safety and tolerability of inhalation of glycopyrronium inhalation powder using different dosing regimens. The second objectives are to determine the decrease in drooling by using different dosing regimens…

Inhibition of salivary glands to reduce uptake of radioactive Iodine

Primary: to determine if inhibition with GPB can provide a significant (>30%) reduction in the accumulation of orally administered Iodine-123 in salivary glands, measured at 4h after administraion. Secondary: to determine if a reduction at 4h…

Inhibition of salivary glands to reduce uptake and toxicity of PSMA-ligands

To determine if inhibition with GPB can provide a significant reduction in the accumulation of systemically administered Ga-PSMA in salivary glands on PET/CT, with the aim to determine if GPB can prevent toxicity from Lu-PSMA or other…