1027 results
Aim of this study is to confirm the results from ex vivo research in humans in a clinical setting. The objective is to perform optical spectroscopy measurements during surgical procedures in vivo, involving resection of either breast, liver or lung…
The aim of this study if PET using [18F] fluorothymidine (FLT), an imaging biomarker, performed at week 10 of concomitant radio/chemotherapy for patients with newly diagnosed GBM is superior to MRI at 10 weeks to evaluate treatment response and to…
Accurately identify the molecular/ biochemical 'fingerprints' of the tissue structures and cell types within normal and malignant mucosa from the oral cavity, in particular the edge of the tongue and the floor of the mouth, based on Raman…
Feasibility of ultra high field 7.0 Tesla MR Spectroscopy for monitoring neo-adjuvant therapy efficacy.
The trial aims to investigate whether procalcitonin measurements can reduce the amount of blood cultures in the ICU safely and cost-effectively.
To compare the diagnostic performance of new lymph node staging methods for prostate cancer (dwMRI fused with 18F-Choline PET-CT) with the current gold standard of staging, the extended pelvic lymph node dissection (ELND)
The overall aim of the proposed longitudinal cohort study is to expand our understanding of health-related work functioning among cancer survivors, who returned to work after first cancer diagnosis and treatment with curative intent during 18 months…
To establish the safety and preliminary efficacy of Check-Cap*s P1 Capsule System in patients eligible for CRC screening
The purpose of this study is to determine the thermal parameters by MRI scans at different time points during head-neck radiotherapy combined with hyperthermia treatment series.
1. To construct a Dutch multicenter prospective biorepository for validation of biomarker and imaging products.2. To provide a Medical Technology Assessment (MTA) of newly developed biomarkers, contrast enhanced ultrasound and multimodality MR Iin…
The primary objective is to assess the contribution of HER2-PET to subsequent anti-HER2-therapy decisions. Secondary objectives are assessment of clinical value of HER2-PET for the referring clinician; correlation of HER2-PET with standard…
Primary Objective: the primary objective of this study is to determine the feasibility of [18F]FDHT PET/CT for in vivo evaluation of bone metastases in prostate cancer. Active locations will be compared with those seen on conventional imaging (bone…
The primary objectives are to determine the diagnostic performance of gadofosveset-enhanced T1-weighted MR imaging for the discrimination between pN0 and pN+ patients for both primary staging and restaging after chemoradiotherapy and to determine…
The aim of this study is to evaluate androgen receptor (AR) and estrogen receptor (ER) expression non-invasively by means of PET imaging with the tracers 18F-FDHT and 18F-FES. To verify the PET results, the standard diagnostic biopsy will be…
1. To investigate the feasibility of photoacoustic breast cancer imaging as embodied in the first generation photoacoustic mammoscope; 2. To correlate the photoacoustic images to conventional diagnosis of the breast and therefore to find…
Non invasive imaging of hypoxia with the aid of PET-scans could help to select the patients having a hypoxic tumor who could be treated with specific anti-hypoxic treatments. The added value of additional anti-hypoxic treatments depends on the…
To detect changes in multiple [18F]fluorodeoxyglucose positron emission tomography * computed tomography ([18F]FDG PET-CT) scans in one patient, test-retest variability needs to be determined, to know when an observed difference is due to a true…
Up front breast surgery in patients with primary distant metastatic breast cancer, will result in an improvement of the 2-year survival compared to the survival achieved with systemic therapy and delayed local treatment or systemic therapy alone.The…
This study aims to design a nomogram for the course of serum pro-calcitonin in burn patients. For this purpose, a new, sensitive assay will be used. It is expected that the nomogram will help to differentiate between patients with a systemic…
In this pilotstudy we are planning to investigate in a relatively low number of patients if [18F]-choline uptake will decrease after 2 to 3 weeks of trastuzumab +/- pertuzumab therapy in morphologically responding patients (as noted after 12 weeks…