191 results
Objective The objective of this study is to assess which risk scoring model is most cost-effective for the discrimination between benign and malignant ovarian tumors that guides referral decisions for women with ovarian tumors in the Netherlands…
Proof of principle of imaging the polyamine concentration with 7 Tesla 1H-MR spectroscopic imaging in patients with prostate cancer
The purpose of this pilot study is twofold: - evaluation of the tumour movement and regression during and short after long course pre-operative therapy for locally advanced rectal cancer in order to develop an integrated or sequential dose…
The aim of our study is to assess the prevalence of cardiac dysfunction and undiagnosed heart failure in women registered in general practice with a history of breast cancer who received chemotherapy and / or radiotherapy as compared to a matched…
The identify the health-related quality of life of elderly patients with resected stage III colon cancer and relate the outcomes to patient and treatment characteristics (surgery alone or surgery plus adjuvant chemotherapy). Furthermore, the impact…
The primary objective of this study is to determine the impact of a diagnosis and type of treatment of cancer, ageing and their interaction on wellbeing of older cancer patients. Furthermore, we aim to determine the different psychosocial…
To identify circulating mediators that are released after surgery and which are responsible for macrophage activation.
This study aims to detect differences in sick leave time, associated costs and quality of life between differentiated thyroid cancer patients treated in either a fast-track protocol or a traditional longer time interval between total thyroidectomy…
This research aims to assess the effect ofn completing an ACA-task on decision-making regarding short-course pre-operative radiotherapy in the treatment of rectal cancer in clinical practice.
The aim of this project is to develop a comprehensive EORTC questionnaire for assessing sexual health for male and female patients with cancer. Given the lack of a sexual health related measure that can be used in clinical trials and in clinical…
The main objective of this study is to determine whether tumor concentrations of kinase inhibitors at pharmacological active doses can be predicted from PET studies using tracer amounts (microdosing) of corresponding radiolabeled kinase inhibitors.…
Rationale: The purpose of this project is to investigate the presence and course of natural WT1-specific and PRAME-specific immunity in EOC patients, with the intent to exploit the obtained knowledge of WT1-specific and PRAME-specific immunity for…
To explore the effect of Eligard® on the following prostate cancer biomarkers:• Testosterone in serum• Prostate Specific Antigen (PSA) in serum• Prostate Cancer Antigen (PCA3 score) in urine • PSA mRNA in blood/PBMC• PCA3 mRNA in blood/PBMC• TMPRSS2…
To evaluate the validity of the SRT for assessing the exercise capacity of patients with cancer during chemotherapy.
1. To validate accelerometer cut-points to asses physical activity and sedentary behavior of breast cancer survivors. 2. To investigate the validity of accelerometers, inclinometers, heart rate and oxygen consumption to assess time spent in…
Primary objectiveThe primary objective of this study is to develop and validate a disease-specific PROM, which measures HRQoL in meningioma patients.
1. To determine the optimal acquisition technique for USPIO enhanced MRI (without contrast injection), DCE (without contrast injection) and DWI and T2* MRI of esophageal cancer in terms of signal-to-noise ratio, time resolution and spatial…
This study aims to identify global and local determinants of HPV vaccine acceptability, HPV vaccine uptake and compliance as well as identify logistics and programmatic issues in each country to offer the HPV vaccine, as a potential cervical cancer…
The primary objective of this study is to analyse the microenvironment of the tumour, (sentinel) lymph nodes (i.e. various T-cell populations, antigen presenting cells and myeloid-derived suppressor cells) in patients with vulvar carcinoma. The…
To assess the physiological effects of metformin and hypocaloric dieting on thyroid iodide uptake and thyroid function in healthy volunteers.