260 results
To ascertain the amount of UV-damage (p53 activation, apoptosis, thymidine dimers and γH2AX) is caused by the Dermasun treatment in psoriasis patients.Total skin check in patients using Dermasun for a prolonged period of time to screen for (pre-)…
In this study, the agreement between liquid biopsy and tissue biopsy based KRAS/EGFR molecular diagnostics will be determined. Additionally, pairwise comparison of different liquid biopsy based molecular tests will be performed based on several…
The aim of this study is to evaluate the use of rapid IO-PTH measurement to predict post-thyroidectomy hypocalciemia.
Primary objective:• To assess the safety and feasibility of adding ipilimumab-nivolumab to a CRT induction protocol• To assess the efficacy of adding ipilimumab-nivolumab to CRT on the likelihood of a pCR and MPRSecondary objectives: • Local and…
This study will evaluate how safe administering obinutuzumab as a short duration infusion (SDI) during cycle 2 and from cycle 2 onwards in combination with chemotherapy in patients with previously untreated advanced FL is.
To investigate the progression-free survival after radiotherapy to a single lesion in patients with stage IV non-small cell lung cancer who achieved at least stable disease with immune therapy alone or concurrent immune therapy and chemotherapy and…
The main objectives of this study is to evaluate if EGFR positive cervical lymph node metastasis can be detected non-invasively using the MSOT Acuity Echo with cetuximab-800CW as contrast agent in patients with oral squamous cell carcinoma.
Primary:- The feasibility of SFR spectroscopy incorporated in an ERCP procedure.Secondary:- Determine physiological differences between benign and malignant biliary strictures, based on the obtained spectra acquired over a broad wavelength range (…
Prone versus supine positioning for rectal cancer irradiation using volumetric modulated arc therapy
The primary aim of the study is to investigate the effect of patient positioning on OARs sparing in rectal cancer patients treated with VMAT (hypothesis 1). The secondary aim of the study is to investigate the possible differences in optimal patient…
The primary objective of this study is to determine histological ablative efficacy by absence of vital (tumour) cells in the treated prostate zone with (multi)fibre setup in men with PCa scheduled for radical prostatectomy. The secondary objectives…
The aim of this pilot study is to interrogate the feasibility of the workflow, using this image-based CAD system real-time in the endoscopy suite.
The primary objective of this study is to compare the overall survival (OS) associated with rAd-IFN, when administered with celecoxib and gemcitabine, versus that associated with celecoxib and gemcitabine alone for the treatment of patients with MPM…
Primary objective:To investigate in Adolescent and Young Adult (AYA) Head and Neck Cancer (HNC) survivors treated with unilateral radiotherapy 5-10 years before, the long-term vascular complications in terms of carotid wall changes (ultrasonography…
This will be an explorative study to examine the value of high-resolution ultrasound (HRUS) of the peripheral nerves in NF1 patients. The primary objective of this study is to determine HRUS abnormalities in a large group of NF1 patients, and to…
The objective of this study is to develop a method whereby reliably can be determined if there are microscopic metastases in the neck lymph nodes of H&N cancer patients. In those patients with "clean" nodes the irradiation can be…
Primary Objective: * To evaluate the ability to concentrate the radiotracer within the prostate gland improving the evaluation of the primary prostate tumor. Secondary Objective(s): * To evaluate the PET/CT imaging characteristics of transcatheter,…
This study has been transitioned to CTIS with ID 2024-517267-23-00 check the CTIS register for the current data. The aim of this research is to investigate whether it is feasible and safe to pre-operatively treat patients who will undergo a distal…
This study has been transitioned to CTIS with ID 2024-518046-25-00 check the CTIS register for the current data. Evaluation of the feasibility of intraoperative visualization of penile and tongue tumours using the fluorescent tracer EMI-137.
Primary objective:- To compare efficacy of induction vemurafenib + cobimetinib followed by ipilimumab + nivolumab (Arm A) versus upfront ipilimumab + nivolumab treatment (Arm B).Secondary Objectives- To describe duration of response and overall…
The purpose of this study is to investigate how quickly and to what extent derazantinib is absorbed (taken up), distributed, metabolized (broken down) and eliminated from the body. The pharmacokinetics of derazantinib when it is administered…