290 results
The aim of the study is to investigate the effect of magnetic resonance (MR) based online adaptive radiotherapy (RT) for treatment of low to intermediate risk localized prostate carcinoma (PCa) on the radiotherapy dose on the prostate and organs at…
This study has been transitioned to CTIS with ID 2024-513412-10-00 check the CTIS register for the current data. Phase 1: • To determine the MTD/RP2D regimen of brigatinib monotherapy when administered in pediatric and AYA patients with ALK+ ALCL or…
Part 1: Dose-Escalation Stage (not in The Netherlands)Primary objective:* Safety and tolerability of HBM4003Secondary objectives:* Preliminary anti-tumor activities of HBM4003 in advanced solid tumors* Pharmacokinetics (PK) of HBM4003Other…
In this study we will investigate how quickly and to what extent the new compound JNJ-67856633 is absorbed, transported, and eliminated from the body. JNJ-67856633 is radioactively labelled with carbon-14 (14C).We also investigate how safe JNJ-…
The primary aim of the study is to assess the prevalence of MDRO carriage in patients undergoing ERCPs. This will be performed in four different countries with expected significantly different prevalence rates of MDRO carriage, namely: India, United…
Primary objectives1. To assess the safety of Tam added to Ven. Venetoclax will be dosed at 800 mg once daily. After 2 days of venetoclax, tamoxifen will be orally administrated in a ramp-up phase (2 days 10mg, 2 days 20mg, to a final dose of 40 once…
Primary Objectives- To determine the optimal dose of the VEGF-A targeting NIRF tracer bevacizumab-IRDye800CW for an adequate tumor-to-background ratio (TBR) in PTC/FTC/HTC/PDTC lymph node metastases.Secondary Objectives- To evaluate the feasibility…
Goal of the UMBRELLA Study is the optimization of existing MRI protocols and processing techniques required for MRI guided radiation treatment on the Marlin system (MRI of the MR-Linac) and diagnostic MRI scanners in the radiology department needed…
The aim of this study is to investigate the concept of fear of progression among advanced incurable cancer patients onongoing systemic treatment.
To add 36 benign control patients to the Expect study to investigate whether detection of a KRAS mutation by ddPCR in peritoneal fluid is truly specific for pancreatic cancer.
Primary objectives- A multicenter, open label non-randomized phase I/II dose escalation study with extension cohort to determine the safety, tolerability and immunogenicity of the therapeutic LRPAP1 synthetic long peptide ( LRPAP7-30V-SLP) vaccine (…
The primary goal is to compare functional (language) areas in the brain found by preoperative fMRI, to those found during intraoperative ESM (electrical stimulation mapping) and fUS (functional ultrasound) during awake craniotomies, to see whether…
This study has been transitioned to CTIS with ID 2024-517846-32-00 check the CTIS register for the current data. To evaluate the effect of prolonged duration of (fos)aprepitant prophylaxis on the prevention of delayed CINV (complete remission in the…
To explore feasibility and efficacy of endoscopic unilateral drainage of patients with presumed perihilar cholangiocarcinoma eligible for major liver resection using a novel fully covered metal stent with a retrieval string.
The primary objective is to examine the feasibility of 68Ga-exendin-4 PET/CT for localizing and characterizing PGL.
Fluorescence guided surgery for intra-operative detection of meningioma using Bevacizumab-IRDye800CW
In the present study, we aim to perform a feasibility study with Bevacizumab-IRDye800CW in patients with meningioma who are scheduled for elective surgical resection. The ability of fluorescence imaging to identify residual meningioma tissue that is…
This study aims to test the hypothesis that zandelisib in combination with rituximab has better clinical activity and risk/benefit profile compared to standard 2nd line immunochemotherapy (R-CHOP/R-B) in subjects with relapsed FL or MZL. Primary…
This study has been transitioned to CTIS with ID 2023-509318-13-00 check the CTIS register for the current data. This is an open-label, multi-center, roll-over study designed to provide continued access to subjects who have previously participated…
The objective of the PoCoMiMo study is to compare the abundance, and hepatic clearance of microbiota-derived molecules in the portal venous circulation between patients suffering from a primary hepatic malignancy versus those with pancreatic cancer…
The aim is to investigate whether it is feasible to perform a 12-weeks nutritional intervention study in NSCLC patients on PD-1 ICI, and to effectively assess their nutritional, immune, and microbial status, with the intention to use this…