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A multicentre single-arm phase II trial of amivantamab, lazertinib plus bevacizumab in patients with EGFR-mutant advanced NSCLC with progression on previous third generation EGFR TKI

This study has been transitioned to CTIS with ID 2024-512288-29-00 check the CTIS register for the current data. The aim of this prospective single-arm phase II study is to evaluate the efficacy of amivantamab and bevacizumab added to continued…

A Phase 2, Multicenter, Randomized, Open-Label Trial of GEN1046 as Monotherapy and in Combination With Pembrolizumab in Subjects With Relapsed/Refractory Metastatic Non-Small Cell Lung Cancer After Treatment With Standard of Care Therapy With an Immune Checkpoint Inhibitor

This study has been transitioned to CTIS with ID 2024-513770-22-00 check the CTIS register for the current data. Primary objective:• Evaluate the anti-tumor activity of GEN1046 as monotherapy and in combination with pembrolizumab in subjects with…

A multicentre single-arm phase II trial assessing the safety and efficacy of
first-line osimertinib and locally ablative radiotherapy in patients with
synchronous oligo-metastatic EGFR-mutant non-small cell lung cancer

The objective of this trial is to evaluate safety (in terms of grade >=2 pneumonitis, requiringmedical treatment) and efficacy (in terms of PFS) in patients with synchronous oligometastatic EGFR-mutant NSCLC treated with osimertinib and…