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A parallel phase II study of Tarceva®(Erlotinib) in patients with advanced non-small cell lung cancer (Stage IIIB/IV) not pre-treated by chemotherapy including dose escalation to toxicity in current and former smokers

To estimate the efficacy of erlotinib administered as a single agent to chemo-naïve NSCLC patients as determined by the non progression rate (NPR) at 8 weeks.

Phase I study of concurrent with involved-field thoracic radiotherapy for inoperable non-squamous cell lung cancer, followed by both concurrent and maintenance Bevacizumab

Primary objectivesTo establish the safety and tolerability of1. two doses of bevacizumab 7.5 mg/kg administered every 3 weeks with concurrent thoracic radiotherapy to 66 Gy;2. concurrent (7.5 mg/kg) and maintenance (15 mg/kg) bevacizumab during, and…

A phase II study to investigate the efficacy of neoadjuvant erlotinib in patients with clinical stage I/II non-small cell lung cancer (NSCLC)

Primary objectives:To determine the objective tumor response (CR + PR) after 3 weeks of erlotinibSecondary objectives: To describe predictive markers for response:- radiological response (FDG-PET/CT)- EGFR mutations (HER1)To determine (diseasefree)…

Lymphoscintigraphy of the pretreated neck in head and neck squamous cell carcinoma

To analyze the value of lymphatic mapping in HNSCC patients with a previously treated neck.

A Phase 1/2 Study Evaluating the Safety and Efficacy of ABT-751 in Combination with Pemetrexed Versus Pemetrexed Alone in Subjects with Advanced or Metastatic Non-Small Cell Lung Cancer

The primary objective of the Phase 2 portion of the study is to assess if the addition of ABT-751 at the RPTD to standard pemetrexed can prolong PFS compared to pemetrexed alone in subjects with advanced or metastatic NSCLC.

A Three Cohort Phase II trial of BMS-275183 given orally on a twice weekly schedule in pretreated locally advanced or metastatic NSCLC patients

The aim of this study is to assess the clinical activity of BMS-275183 in patients who have failed prior treatment.

Lobectomy for the treatment of non-small cell lung cancer (NSCLC):
video-assisted minithoracotomy (VAMT) versus muscle-sparing thoracotomy (MST)

see K1

Prospective study on cost-effectiveness of the Provox®2 and the Groningen Ultra Low Resistance tracheoesophageal shunt prostheses in voice rehabilitation of post-laryngectomy patients.

The objective of the study is a prospective study to evaluate which type of TE shunt prosthesis is the most cost-effective.

FDG-PET for avoidance of futile neck dissections after non-surgical treatment of advanced head and neck cancer

To study the diagnostic accuracy of FDG PET and MRI as a function of time in the response monitoring and detection of residual lymph node metastases after non-surgical treatment of advanced head and neck cancer.