13 results
Investigate the association between BRCA1/2-mutations, DNA damage, apoptosis and oocyte/embryo quality in immature germinal vesicle (GV) bearing oocytes, immature metaphase 1 (MI) and unfertilized mature metaphase 2 (MII) oocytes and affected early-…
To determine the effects of biphosphonates on radiation induced microvascular damage in the skin of breast cancer patients by comparing skin biopsies taken prior to and 4 months after treatment with a biphosphonate.
Primary Objective: 1. A search for (objective) EEG predictors (independent variables) for both acute and chronic postoperative pain (dependent variables) after breast cancer surgery. The EEG variables are derived from the above mentioned five…
We intend to study the effect of trastuzumab on the cardiac neuronal activity in patients with HER-2 positive breast cancer by using iodine-123 meta-iodobenzylguanidine (123I-MIBG) and cardiac imaging. 123I-MIBG, an analogue of the false…
Primary Objective: Does long-term endocrine adjuvant treatment for breast cancer lead to structural changes in the brain and to functional changes in brain-wide networks, and do these changes correlate with cognitive impairment induced by the…
The BASIS study will analyze the full cancer genome of breast cancer subtype ER+ HER2-.
Analyze processes related to DNA-damage in oocyte development and early-developmental stage embryos from BRCA1/2-mutation carriers compared to controls, using immunohistochemistry and RNA-Seq technology.
The aim of this study is to define the specific changes in skeletal muscle composition and function, systemic inflammation and nutritional intake and physical activity levels, during cancer treatment. To investigate this, we will include 13 female…
The study objectives are:1. Getting insight into the biological origin of the typical serum protein profile in breast cancer by comparing the protein profiles in breast tissue of benign breast disease patients and primary breast cancer patients with…
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Investigate the consequences of axillary lymph node dissection (ALND) and sentinel lymph node procedure (SNP) regarding shoulder impairments, the activities a women still undertakes and the role of quality of life and anxiety in this in women who…
Hypothesis.In women with preeclampsia endovascular remodeling and invasion of the spiral arteries is less prominent which will result in overwhelming placental oxidative stress and pregnancy failure. Abnormal function of trophoblast and stroma cells…
To investigate the effect of a 6-month exercise programme on cognitive problems in chemotherapy-exposed breast cancer patients who have cognitive problems (both on the self-report level and by formal assessment). Furthermore, we are specifically…