34 results
To assess, based on a woman*s risk profile, mammographic density and age, the most cost-effective screening method, mammography or MRI, for women at high risk.
To establish biomarkers in nipple aspirate fluid, follow them in time and link them to breast cancer development at its earliest stage in women at high risk for breast cancer. Threshold values of biomarkers will be determined that point to a…
The aims of this project are to:1. Assess what percentage of breast cancer patients experience accelerated gain in fat mass, loss of muscle mass and muscle strength as induced during chemotherapy2. Assess whether changes in energy intake, protein…
Objective 1: To collect information on risk factors and biomarkers in a screening cohort, develop a tailor-made risk prediction model and, subsequently, model the impact of adapting breast cancer screening policy to populations at varying levels of…
Investigate the association between BRCA1/2-mutations, DNA damage, apoptosis and oocyte/embryo quality in immature germinal vesicle (GV) bearing oocytes, immature metaphase 1 (MI) and unfertilized mature metaphase 2 (MII) oocytes and affected early-…
We want to investigate wether a para-vertebral block contributes to a reduced postoperative pain and morphine consumption in patients with breast cancer after a unilateral mastectomy or lumpectomy. By doing this investigation we hope to clarify,…
The objective of this study is to investigate effects of different forms of patient information on chemotherapy side effects, in particular, assessing the severity and duration of the negative effects of information on chemotherapy-associated…
To determine the effects of biphosphonates on radiation induced microvascular damage in the skin of breast cancer patients by comparing skin biopsies taken prior to and 4 months after treatment with a biphosphonate.
Primary Objective: 1. A search for (objective) EEG predictors (independent variables) for both acute and chronic postoperative pain (dependent variables) after breast cancer surgery. The EEG variables are derived from the above mentioned five…
To compare dose homogeneity and heart and lung doses in supine and prone position. Furthermore, the reproducibility of prone position will be compared to standard supine position, and we aim to identify those patients who benefit most from prone…
To investigate that in mamma surgery, regional infiltration with ropivacaine 0,75% added to general anaesthesia causes less postoperative pain, nausea and vomiting compared to general anaesthesia alone.
We intend to study the effect of trastuzumab on the cardiac neuronal activity in patients with HER-2 positive breast cancer by using iodine-123 meta-iodobenzylguanidine (123I-MIBG) and cardiac imaging. 123I-MIBG, an analogue of the false…
Primary Objective: Does long-term endocrine adjuvant treatment for breast cancer lead to structural changes in the brain and to functional changes in brain-wide networks, and do these changes correlate with cognitive impairment induced by the…
The BASIS study will analyze the full cancer genome of breast cancer subtype ER+ HER2-.
Analyze processes related to DNA-damage in oocyte development and early-developmental stage embryos from BRCA1/2-mutation carriers compared to controls, using immunohistochemistry and RNA-Seq technology.
The aim of this study is to define the specific changes in skeletal muscle composition and function, systemic inflammation and nutritional intake and physical activity levels, during cancer treatment. To investigate this, we will include 13 female…
Primary Objective: To examine the effects of equivalent weight loss with and without exercise on breast cancer biomarkers (endogenous sex hormones) in overweight, sedentary postmenopausal women.Secondary Objective(s): To examine the effects on body(…
·To compare the serological response to influenza vaccination in mamma carcinoma patients treated with FEC-containing, triweekly regimens at day 4 ( +/- 1 day) of the chemotherapy cyclus with the response to vaccination in otherwise healthy patients…
Riskreduction of developing breast carcinoma by means of better surgical techniques (removing all normal breast tissue).
The study objectives are:1. Getting insight into the biological origin of the typical serum protein profile in breast cancer by comparing the protein profiles in breast tissue of benign breast disease patients and primary breast cancer patients with…