30 results
To investigate whether an adjunctive YBSR program added to standard care compared to standard care alone, can reduce:1.fatigue symptoms (primary objective)2.psychological distressand improve:3.health-related quality of life4.sense of coherence5.…
Investigate the association between BRCA1/2-mutations, DNA damage, apoptosis and oocyte/embryo quality in immature germinal vesicle (GV) bearing oocytes, immature metaphase 1 (MI) and unfertilized mature metaphase 2 (MII) oocytes and affected early-…
To study prevalence and consequences of cognitive, psychological, social and functional decline in elderly breast cancer patients, in comparison to a population elderly without breast cancer.
The aim of this study is to determine the effectiveness of the treatment (breast reconstruction) from the perspective of the patient's. By examining the results, the impact on the well-being and satisfaction, we will be able to customize the…
To determine the effects of biphosphonates on radiation induced microvascular damage in the skin of breast cancer patients by comparing skin biopsies taken prior to and 4 months after treatment with a biphosphonate.
Primary Objective: 1. A search for (objective) EEG predictors (independent variables) for both acute and chronic postoperative pain (dependent variables) after breast cancer surgery. The EEG variables are derived from the above mentioned five…
Optimalisation of genetic counseling for patients with breast cancer, by also making use of other ways to provide information than the personal consultation.
We intend to study the effect of trastuzumab on the cardiac neuronal activity in patients with HER-2 positive breast cancer by using iodine-123 meta-iodobenzylguanidine (123I-MIBG) and cardiac imaging. 123I-MIBG, an analogue of the false…
The objective of the study is to assess which outcomes are most important to patients, so that we can inform them better and contribute to decision making. If patients, depending on treatment or age, consider PROMSs more or less important than…
Primary Objective: Does long-term endocrine adjuvant treatment for breast cancer lead to structural changes in the brain and to functional changes in brain-wide networks, and do these changes correlate with cognitive impairment induced by the…
The BASIS study will analyze the full cancer genome of breast cancer subtype ER+ HER2-.
1. Developing novel approaches to determine the clinical significance of UVs. 2. Developing new clinical guidelines and implement them into clinical practice.
Analyze processes related to DNA-damage in oocyte development and early-developmental stage embryos from BRCA1/2-mutation carriers compared to controls, using immunohistochemistry and RNA-Seq technology.
The aim of this study is to define the specific changes in skeletal muscle composition and function, systemic inflammation and nutritional intake and physical activity levels, during cancer treatment. To investigate this, we will include 13 female…
Primary Objective: To examine the effects of equivalent weight loss with and without exercise on breast cancer biomarkers (endogenous sex hormones) in overweight, sedentary postmenopausal women.Secondary Objective(s): To examine the effects on body(…
The objective of this study is to find answers to the question which breast reconstruction technique gives the highest quality of life for these women. Researching the outcome, psycho social and quality of life impacts on women who undergo breast…
The primary aim of the study is to identify breast cancer patients who experience objective and/ or subjective cognitive dysfunction one year after chemotherapy and find determinants of this cognitive dysfunction on patients' quality of life…
The aim of the study will be to examine the relationship between personality, QoL and diurnal cortisol rhythm in women with a suspicion of breast cancer with regard to morbidity, prognosis and mortality.
The study objectives are:1. Getting insight into the biological origin of the typical serum protein profile in breast cancer by comparing the protein profiles in breast tissue of benign breast disease patients and primary breast cancer patients with…
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