20 results
In this non-inferiority study, we aim to identify the diagnostic value of indocyanine green (ICG) fluorescence imaging for SLN mapping versus the standard-of-care 99mTc in the SLN procedure for breast cancer patients.
To assess a pilot-study on the impact of removal versus preservation of the pectoral fascia on total drain volume, time to drain removal and needle aspirations (and thus seroma) in women undergoing bilateral prophylactic mastectomy.
The primary objective of this study is to demonstrate that our DLA-based method is promising enough to detect CTCs in ER+, N+ primary breast cancer patients after 5 years ET. Simultaneously, other methods (CTC detection in 7.5 ml and 30 ml of blood…
Our study aim is to assess whether it is feasible to remove small breast cancers completely using VAB under US guidance.
The overall study aim is to determine the efficacy rate of complete ablation for the most promising types of thermal ablation (RFA, MWA or CA) technique for patients with early stage breast cancer (cT1N0M0) without an extensive component of DCIS (…
To determine the potential pharmacokinetic interaction between CBD and endoxifen.Secondary objective: To investigate side effects of CBD and to determine the pharmacokinetic profile of CBD
To determine the activity (as measured by objective response rate by RECIST1.1) of monalizumab and trastuzumab in patients with metastatic HER2-positive breast cancer.
Primary ObjectivesSafety run-in Part 1:To confirm the recommended dose of alpelisib in combination with trastuzumab and pertuzumab for Part 2.Double-blind, randomized, placebo-controlled Part 2:To determine whether treatment with alpelisib in…
This study has been transitioned to CTIS with ID 2024-516653-44-00 check the CTIS register for the current data. The primary purpose of the study is to determine the efficacy and safety of T-DXd compared with investigator*s choice single agent…
Primary: To investigate the performance of the PAM3(+) device in breast cancer imaging. With the performance we mean:1. The ability to visualize blood vessels and tumors in the mammary gland (PA)2. To extract oxygenation saturation estimations (QPAT…
The primary objective of this study is to determine whether SAR439859 in combination with palbociclib improves progression free survival (PFS) compared to letrozole in combination with palbociclib in patients with ER +, HER2-advanced breast cancer…
This study has been transitioned to CTIS with ID 2024-513217-12-00 check the CTIS register for the current data. To determine the activity and safety of nivolumab (as monotherapy or in combination with other immunomodulatory treatments) after…
This study has been transitioned to CTIS with ID 2023-507961-24-00 check the CTIS register for the current data. Primary objective:1. To evaluate IDFS with T-DXd treatment as compared to T-DM1Secundary objectives:1. To evaluate DFS with T-DXd…
Primary Objective: To study trial feasibility in terms of patient enrollment and the percentage of tumor biopsies that can be assessed successfully.Secondary Objective(s): To study preliminary effects of exercise on immune function and generate…
The primary objective is to identify the relevant domains of health-related quality of life as experienced by patients who are previously treated with neoadjuvant chemotherapy for HER2-positive breast cancer. Secondary Objectives: * To adjust…
The aim of this prospective randomized, double blind placebo-controlled trial study is to evaluate the analgesic effects of preoperative PECS-II block in addition to general anaesthesia for breast conserving surgery compared to a placebo block. Our…
To determine the difference in change over time of cognitive function and brain magnetic resonance imaging (MRI) measurements between breast cancer survivors and cancer-free individuals.
The primary objective of this study is to assess the univariate association between RILA frequency and RIF after BCT and radiotherapy among breast cancer patients. Secondary objectives include: the identification of treatment and patient related…
To determine the influence of concomitant administration of tamoxifen and probenecid on tamoxifen and endoxifen(-glucuronide) plasma concentrations
To determine the the impact of 30% daily caloric restriction or daily exercise training on tumor and muscle tissue protein synthesis rates in breast cancer patients.