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Role of oncogenes in chromosome region 17p11.2-p12 in osteosarcoma tumorigenesis

The purpose of this investigation is identify thecausative oncogenes in 17p11.2-p12, to clarify the mechanism of their amplification, and to determine their diagnostic and prognostic importance for patients with osteosarcoma.

Defining optimal imaging strategies for diagnosis, treatment, and treatment evaluation of chordomas and chondrosarcomas of the axial skeleton

Show that functional MR tumor plasma volume parameters Vp,max and Vp,mean change significantly within 1-6months following start of proton beam radiotherapy of chordoma.